ID R0KZ16_NOSB1 Unreviewed; 876 AA.
AC R0KZ16;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:EOB15422.1};
GN Name=IDE {ECO:0000313|EMBL:EOB15422.1};
GN ORFNames=NBO_4g0050 {ECO:0000313|EMBL:EOB15422.1};
OS Nosema bombycis (strain CQ1 / CVCC 102059) (Microsporidian parasite)
OS (Pebrine of silkworm).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX NCBI_TaxID=578461 {ECO:0000313|EMBL:EOB15422.1, ECO:0000313|Proteomes:UP000016927};
RN [1] {ECO:0000313|EMBL:EOB15422.1, ECO:0000313|Proteomes:UP000016927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQ1 / CVCC 102059 {ECO:0000313|Proteomes:UP000016927};
RX PubMed=23496955; DOI=10.1186/1471-2164-14-186;
RA Pan G., Xu J., Li T., Xia Q., Liu S.L., Zhang G., Li S., Li C., Liu H.,
RA Yang L., Liu T., Zhang X., Wu Z., Fan W., Dang X., Xiang H., Tao M., Li Y.,
RA Hu J., Li Z., Lin L., Luo J., Geng L., Wang L., Long M., Wan Y., He N.,
RA Zhang Z., Lu C., Keeling P.J., Wang J., Xiang Z., Zhou Z.;
RT "Comparative genomics of parasitic silkworm microsporidia reveal an
RT association between genome expansion and host adaptation.";
RL BMC Genomics 14:186-186(2013).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; KB908912; EOB15422.1; -; Genomic_DNA.
DR AlphaFoldDB; R0KZ16; -.
DR STRING; 578461.R0KZ16; -.
DR EnsemblFungi; EOB15422; EOB15422; NBO_4g0050.
DR VEuPathDB; MicrosporidiaDB:NBO_4g0050; -.
DR HOGENOM; CLU_328204_0_0_1; -.
DR Proteomes; UP000016927; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 1.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000016927};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 44..142
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
SQ SEQUENCE 876 AA; 103799 MW; 9A5FED89BC42A088 CRC64;
MIWFLTFVFC SHYEIFDAIE RPKRFFFKLE NDMPVLFIGT DSKYSRFSYS VNTGSVDDFK
DCKGISHLLE HCLFGVDTEL LKFIYDHGGS IIACTDESAI TFEYLILKEY FNESLEILFR
ALNNPIFNPK AVNDEINLVD QEFRYRSVNN CVASNLCGEI NELDVFTTGN SKALLLENIG
LRLEQLYKNN FFKYNGSILC ITDASIHFIQ KYNLNYEQKP QNRIKKTLLT DYYNIDERLF
LIKSSSNILF LRIKVPLEES PFLLNFLINE YLYRLGSFKS ISKYVYSVDH MNIYHVVNIN
LFIEEDQCIH PRLFINQFIE IIKTTQIPIK EYESLLKETY NSVAKDVKPL DFLDYSNIHR
YIQFKPYLFE KDFDKKNLLK FNKEQFKSLI KHLTDSSNYS VLYECDVNGP IKHSTYNDIP
YTSLRKGCSP YYLVACDPKE DDVPVNPIES SLYCVMVREN EDLNQKGHRS ELRSDPRFNP
EDLIDINYND FLQSSSLKAE RYIEDDYYKI DEAPTYKIHY IHLKDTEDKI LILRFYINEN
YEDFMKLIYL MGCLELALNN SLNLQRSNRA TFKIKHNMLE VLFLKTSDRN HRLIVTKYIS
MCMKTLVQYL NAIKSSSDSL ITIKMKEIAE NVYGKYGLER DFRKLTKSAF SLYDSKRMKV
MPPFYLKIGF LGRTNLLLQD EITDMVRKIK PDLKYTDLKK DIDGFSSSIP MLKKYSRFSL
YVVDQLELSI RYVVVRLCTH FALYKYVESL RIDDKIGYHV FADYTSETYY SNFSIEGYSI
KDDFETKRIL WEYVVTVMNS LSNMSREEFT TFLEVVYNTY KLRSNNIKEI FHFCRSLDFQ
IDYRTFNEEF KTNLYSEFIK EDIILMLETE VSSLMD
//
