ID R0L1L6_ANAPL Unreviewed; 221 AA.
AC R0L1L6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Src kinase-associated phosphoprotein 2 {ECO:0000313|EMBL:EOA99468.1};
DE Flags: Fragment;
GN ORFNames=Anapl_07956 {ECO:0000313|EMBL:EOA99468.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA99468.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SKAP family.
CC {ECO:0000256|ARBA:ARBA00005864}.
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DR EMBL; KB743319; EOA99468.1; -; Genomic_DNA.
DR AlphaFoldDB; R0L1L6; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037781; SKAP_fam.
DR PANTHER; PTHR15129:SF2; SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 2; 1.
DR PANTHER; PTHR15129; SRC-ASSOCIATED ADAPTOR PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW B-cell activation {ECO:0000256|ARBA:ARBA00022936};
KW Kinase {ECO:0000313|EMBL:EOA99468.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:EOA99468.1}.
FT DOMAIN 1..91
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 159..220
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOA99468.1"
FT NON_TER 221
FT /evidence="ECO:0000313|EMBL:EOA99468.1"
SQ SEQUENCE 221 AA; 25714 MW; B0039640EE40B50C CRC64;
DHSFLGFEWQ KRWCVISKTV FYYYGSDKDK QQKGEFALEG YTIRMNNNLR KDAKKDCCFE
ISAPDKRIYQ FAAATPKEAE EWVQQVKFVI QDMESNTIPE EEEEYDDVGQ ASSEPIDDSI
YEELPVMCFA EESASPKAEV PRKWSQEKVT TVSDGKNTDY ANFYQGLWDC TGDVPDELSF
KRGDVIYILS KEYNRFGWWV GEMKGTIGLV PKAYIMEMYD I
//
