ID R0M1B5_ANAPL Unreviewed; 473 AA.
AC R0M1B5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=WSC domain-containing protein 2 {ECO:0000313|EMBL:EOB06463.1};
DE Flags: Fragment;
GN ORFNames=Anapl_14190 {ECO:0000313|EMBL:EOB06463.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB06463.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR EMBL; KB742615; EOB06463.1; -; Genomic_DNA.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF7; WSC DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..229
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB06463.1"
FT NON_TER 473
FT /evidence="ECO:0000313|EMBL:EOB06463.1"
SQ SEQUENCE 473 AA; 53636 MW; C46587162A175C7D CRC64;
RDEDAMAKFL VKFQRYFRRR PVRFFTLLAL YLAAGSLVFL HAGFTRGPWF KSTAKEPAER
SKVGDYGAAR SRLLKGRSGC GKEEDRAKYI GCYVDSTRRR TLRGVSFLDY KKMTVFRCQD
NCAEXGKLSK NPIRATLTSC TPTISPPVPP PDGSAVFRGF ALPASQPMPN MSVDKCVDFC
TEKVPGGLRP CPAHLGLIRE DEQLCAQRCP GEEFESCGTP EFLLVYQTQV QEKREPPGRA
PVPCISQLLV ALASFPGAGN TWARHLIELA TGFYTXXXXY YFDGSLYNKG FKGERDHWRS
GRTICIKTHE SGQKEIESFD SAILLIRNPY KALMAEFNRK YGGHIGFAAH AHWKGKEWPE
FVANYAPWWA THTLDWLRYG RKVLVVHFED LKRDLFAQLK RMVGLLGIAA CEDRLLCVEG
QKDGNFKRSG LRKLEYDPYT PEMRKMISGY IKTVDAALKL RNLSGVPEDY YPR
//
