ID   R0MEK1_STRMT            Unreviewed;       171 AA.
AC   R0MEK1;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Transcriptional regulator {ECO:0008006|Google:ProtNLM};
GN   ORFNames=D065_01651 {ECO:0000313|EMBL:EOB33346.1};
OS   Streptococcus mitis 13/39.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1239793 {ECO:0000313|EMBL:EOB33346.1, ECO:0000313|Proteomes:UP000013315};
RN   [1] {ECO:0000313|EMBL:EOB33346.1, ECO:0000313|Proteomes:UP000013315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13/39 {ECO:0000313|EMBL:EOB33346.1,
RC   ECO:0000313|Proteomes:UP000013315};
RA   Ikryannikova L.N., Ilina E.N., Kostryukova E.S., Semashko T.A.,
RA   Karpova I.Y.U., Larin A.K., Ischenko D.S., Alekseev D.G., Klimova E.A.,
RA   Filimonova A.V., Savinova T.A., Filimonova O.Y.U., Dubovickaya V.A.,
RA   Sidorenko S.V., Govorun V.M.;
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOB33346.1}.
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DR   EMBL; AQTU01000004; EOB33346.1; -; Genomic_DNA.
DR   AlphaFoldDB; R0MEK1; -.
DR   PATRIC; fig|1239793.3.peg.319; -.
DR   Proteomes; UP000013315; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 3.30.1340.20; 3H domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR035922; 3H_dom_sf.
DR   InterPro; IPR004173; 3H_domain.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR026043; NadR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR40068; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR   PANTHER; PTHR40068:SF1; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR   Pfam; PF02829; 3H; 1.
DR   Pfam; PF08279; HTH_11; 1.
DR   PIRSF; PIRSF037847; NiaR; 1.
DR   SUPFAM; SSF75500; Putative transcriptional regulator TM1602, C-terminal domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037847-1};
KW   Nickel {ECO:0000256|PIRSR:PIRSR037847-1}.
FT   DOMAIN          5..57
FT                   /note="Helix-turn-helix type 11"
FT                   /evidence="ECO:0000259|Pfam:PF08279"
FT   DOMAIN          72..168
FT                   /note="3H"
FT                   /evidence="ECO:0000259|Pfam:PF02829"
FT   BINDING         76
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT   BINDING         84
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT   BINDING         143
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT   BINDING         145
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
SQ   SEQUENCE   171 AA;  19673 MW;  1DF3C830B47922F2 CRC64;
     MTKDRKQALL QLLKETPKAL NGQSLAEHFH VTRQVIVQDI AILRADGAPI LSTNRGYVYK
     QIETNPYVHK LFKVKHEVEE IGQELLAIVD NGGRVQNTLI DHPVYGEIET LLKLSCRRDV
     QHFLEQVEHS DFRPLSELTD GIHYHLVEAE TQQDLHYIEE ALDQLGYLVK D
//