ID R1CKM4_EMIHU Unreviewed; 1592 AA.
AC R1CKM4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Myosin {ECO:0008006|Google:ProtNLM};
GN ORFNames=EMIHUDRAFT_461238 {ECO:0000313|EMBL:EOD23137.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD23137.1};
RN [1] {ECO:0000313|EMBL:EOD23137.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD23137.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD23137}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RutC family.
CC {ECO:0000256|ARBA:ARBA00010552}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KB865668; EOD23137.1; -; Genomic_DNA.
DR RefSeq; XP_005775566.1; XM_005775509.1.
DR STRING; 2903.R1CKM4; -.
DR PaxDb; 2903-EOD23137; -.
DR EnsemblProtists; EOD23137; EOD23137; EMIHUDRAFT_461238.
DR GeneID; 17268684; -.
DR KEGG; ehx:EMIHUDRAFT_461238; -.
DR eggNOG; KOG0160; Eukaryota.
DR HOGENOM; CLU_244667_0_0_1; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00124; MYSc; 1.
DR CDD; cd06150; YjgF_YER057c_UK114_like_2; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.1330.40; RutC-like; 1.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR019897; RidA_CS.
DR InterPro; IPR035959; RutC-like_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR006175; YjgF/YER057c/UK114.
DR InterPro; IPR035709; YoaB-like.
DR PANTHER; PTHR13140:SF856; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01042; Ribonuc_L-PSP; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF55298; YjgF-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS01094; UPF0076; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1592
FT /note="Myosin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014590401"
FT DOMAIN 176..806
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 942..1053
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1082..1201
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1211..1316
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1213..1576
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 652..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..705
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 244..251
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1592 AA; 180718 MW; 43D66762C35321E1 CRC64;
MWQNALATAG WVLAALLLAR LKRSQPLTRI GVSAKLPFAH AVVAGDVVYL SGVTAQADGD
PIRESDSVEQ QTRRVLRVID ERLSRAGTDN SRVVQAQVWL KDIGRDFAGM NAAWNEWVGD
DDKPTRATVE AALAKPAMLV EIQALSMSAP PDWEPCSLGR NGEGNADTFL KRNHGYGYND
MIALPTLTKD SLLENLARRY KYEVVYTYVG DIVVSVNPFK NALVDHAYNE MVRNEKSQSI
LISGESGAGK TEAMKIALSY IGEVSAKKGQ RVSDEVASRL MQTNPIMEAL GNAKTVRNNN
SSRFGKHFDV QFSANGVIIG AFTSAYLLEK PRITVHLEGE RNYHVFYMLA KAPAAVRESL
GLTKWQDYKI CNQKGTVAEV TTWNDAAEFE DMHEALLKVG FTEEARLELY KMLVFVLQLG
NLDFKPGKEG SEAKDPKQVT PQQLMDAISY RTMGGGKLST YKVPLEPRAA TAARNSLCAH
IYCLVFDCVV SVINDYISVY NAAHCVGLLD IFGFENFKTN SFPQLCINFT NESLHNLFIE
HVFKLEQEVY VKEEVEWNFV SYEDNQHIID LIAKRPICVL GLLDEGCATG SGKDSTDRTF
VLSHYAGEVV YTIEGWVEKN KDELSPDVLM LLEVHSQFER LSELARADTQ KKLEAAESKA
KPGKRGGGGM KKKTVAKTFS EQLATLMEKL RATEHHYIRC LKPNQTLQAG DWDNDFMFKQ
LAYSGTLEVT QIRKAGLNVR RPLKHFYQYY KICADDPSAL RAGTVTKRTE LLLKQLGVDE
NKYRVGKTLL FLLNFEIMEQ LDAIRTERVA EYVIILQSYM RMLKPLLHYK RAKRCILRLQ
GFCKSWEIRR AYCEVRAAAK LLERWTRTYL AHQKLLDMRE SDDPALTPDK KREALLKILY
PAKHGRGRIG LSGKRRPLRI QPTRTVGDDA DEDEFVEMPR FEVAYEGWLV CKVGQMGKYE
KRYVSLKQGT LSLYVDHEAL QVVHSLNMAS CAVSLKSAAI EVRRADGAGL FLQKRRRFKA
SRWGGGDVVV FQRDSLAPEA SEAWAEKLQA SAGEARAVDG YKMQVSLDGD QDEKPVDQKV
AAVIKEGYLR KKKEGTFGKW ERRFFVLYND GKLRYYESKA KAEEKGAVDL RWFALKEVEE
EMEVAEDDTG ESAGLRVQGQ LFKVVKGKQF SLISGKHALY MASPERELCD EWIATLQQTL
ALLYQKSPFF NPEVLRVYMM DGSFTSIPLT ENTHGRDVAR FMCKKHGLNN ETEWGLLELW
DHPGIAGNMT ERKLPGDELL LDQTLVNWER AARIRFGIIS QVPASSFRLV MRKVTSLLPQ
ARTKKEQQLE FCQAMSDLRE GRFTSPDNSE IFDLAALAIF KDLKEGMTEE EQDDDLEGQL
TDQLHNYLPS HMFRALANKR RGLQDSMVEE WDRKVVRAFN ELTRAELIET ESMSEVRRIV
QSFRMETELN AVAATRMCIE RVRLAPLCFS AQYIAEMWSV DKILKVLVVI NAGGLHVYRL
GPSPVLISTF NFDTLVSWQS MNDMLIINII YATKHDHNKR RASAPLQREK LRFLTREAIH
MRNILTKYAE VVLANLVKRM RERDAMQRED DN
//
