GenomeNet

Database: UniProt
Entry: R1CNN9_EMIHU
LinkDB: R1CNN9_EMIHU
Original site: R1CNN9_EMIHU 
ID   R1CNN9_EMIHU            Unreviewed;       836 AA.
AC   R1CNN9;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   07-JUN-2017, entry version 25.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=EMIHUDRAFT_64876 {ECO:0000313|EMBL:EOD24553.1};
OS   Emiliania huxleyi (Pontosphaera huxleyi).
OC   Eukaryota; Haptophyceae; Isochrysidales; Noelaerhabdaceae; Emiliania.
OX   NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD24553.1};
RN   [1] {ECO:0000313|EMBL:EOD24553.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD24553.1};
RG   DOE Joint Genome Institute;
RA   Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Allen A., Bidle K., Borodovsky M., Bowler C.,
RA   Brownlee C., Claverie J.-M., Cock M., De Vargas C., Elias M.,
RA   Frickenhaus S., Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A.,
RA   Herman E., Iglesias-Rodriguez D., Jones B., Lawson T., Leese F.,
RA   Lin Y.-C., Lindquist E., Lobanov A., Lucas S., Malik S.-H.B.,
RA   Marsh M.E., Mock T., Monier A., Moreau H., Mueller-Roeber B.,
RA   Napier J., Ogata H., Parker M., Probert I., Quesneville H., Raines C.,
RA   Rensing S., Riano-Pachon D.M., Richier S., Rokitta S., Salamov A.,
RA   Sarno A.F., Schmutz J., Schroeder D., Shiraiwa Y., Soanes D.M.,
RA   Valentin K., Van Der Giezen M., Van Der Peer Y., Vardi A., Verret F.,
RA   Von Dassow P., Wheeler G., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA   Glockner G., John U., Richards T., Worden A.Z., Zhang X.,
RA   Grigoriev I.V.;
RT   "Genome variability drives Emilianias global distribution.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblProtists:EOD24553, ECO:0000313|Proteomes:UP000013827}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCMP1516 {ECO:0000313|EnsemblProtists:EOD24553,
RC   ECO:0000313|Proteomes:UP000013827};
RX   PubMed=23760476; DOI=10.1038/nature12221;
RA   Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA   Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA   Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D.,
RA   de Vargas C., Verret F., von Dassow P., Valentin K., Van de Peer Y.,
RA   Wheeler G., Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G.,
RA   John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.,
RA   Allen A.E., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA   Cock J.M., Elias M., Gladyshev V.N., Groth M., Guda C., Hadaegh A.,
RA   Iglesias-Rodriguez M.D., Jenkins J., Jones B.M., Lawson T., Leese F.,
RA   Lindquist E., Lobanov A., Lomsadze A., Malik S.B., Marsh M.E.,
RA   Mackinder L., Mock T., Mueller-Roeber B., Pagarete A., Parker M.,
RA   Probert I., Quesneville H., Raines C., Rensing S.A.,
RA   Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA   van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L.;
RT   "Pan genome of the phytoplankton Emiliania underpins its global
RT   distribution.";
RL   Nature 499:209-213(2013).
RN   [3] {ECO:0000313|EnsemblProtists:EOD24553}
RP   IDENTIFICATION.
RG   EnsemblProtists;
RL   Submitted (JAN-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB865427; EOD24553.1; -; Genomic_DNA.
DR   RefSeq; XP_005776982.1; XM_005776925.1.
DR   EnsemblProtists; EOD24553; EOD24553; EMIHUDRAFT_64876.
DR   GeneID; 17270099; -.
DR   KEGG; ehx:EMIHUDRAFT_64876; -.
DR   KO; K02154; -.
DR   Proteomes; UP000013827; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000013827};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    431    457       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    478    496       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    560    581       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    593    613       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    655    676       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    770    794       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       98    132       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   836 AA;  92939 MW;  C3FFE5269F221542 CRC64;
     MASLCPKGEL WRSKKMQLVQ LIVQNDAAHA VMSHLGELGK MQMRDLNAGT SFYKRSFVDE
     VRECDELGRI LRSIGDELDA AGIKPAQTRV DVLELPELGK VDTQLREVEV ELESLKASQA
     LFEKNHNALE EQAIVLAMGK NFYNTGEGAL ASRELEADNE LLSLSEFGAP SRWRGHRPSP
     APPPPLTGPP RALSSMLGVV AGVVKTEFVA SLERILFRAT RGNCVFQQKR IKKLLLDAGT
     AKDGPELTQK SFFMVFFTGG VLGDKVSKIA TYFGATLYKY PDLPGEHARM VVEVDRRLTE
     SSEVLARSTA ILNNALQRCA HDYALWTHVV GREKMVYDAL NKCEFDIKRH VFIAEGWVCT
     DEYEMIHAEL QRAAISRGLD TRPIMNQLRS RLTPPTYVPT NSFTSGFQAL VNTYGTPRYR
     EVNPGAFCCI LFPYLFGIMF GDFGHGLLFA LFGLYLISKE KEWEGKDLGD MLEMVYGGRY
     ICFLNGVFGA FVGLLYNEAF AFPMGFFGTS RWLGPGGETC ANGEDCELSP ELGIYPVGID
     PIWHVTENKI TFFNSLKMKI SIVVGVLQMS LGVFLSLLNH LEYKDYKKVV FQFIPEIVFF
     EGIFGYLVLT IFYKWATDCG PDGSTVGSYV DKLGPNAGQL KVCISPMQSS IQGTLLIAAF
     CAVPVLLLAI PFIEIYQHSG KRGNQSYANL DDDTDGAQPA PAGEEHHEFS AGDAFIHQGI
     HTIEFVLGGI SNTASYLRLW ALSLAHSQLA ELFKDMILGS GLKSRIENPY LAAFVLFIAF
     SMWAIISLVV LMAMENLSSF LHALRLQWVE FQNKFYYGDG QKFSPFTFAA IGQAEE
//
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