ID R1D9S8_EMIHU Unreviewed; 777 AA.
AC R1D9S8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Mitochondrial cardiolipin hydrolase {ECO:0000256|ARBA:ARBA00040549};
GN ORFNames=EMIHUDRAFT_106373 {ECO:0000313|EMBL:EOD07631.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD07631.1};
RN [1] {ECO:0000313|EMBL:EOD07631.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD07631.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD07631}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the phospholipase D family. MitoPLD/Zucchini
CC subfamily. {ECO:0000256|ARBA:ARBA00038012}.
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DR EMBL; KB869279; EOD07631.1; -; Genomic_DNA.
DR RefSeq; XP_005760060.1; XM_005760003.1.
DR PaxDb; 2903-EOD07631; -.
DR EnsemblProtists; EOD07631; EOD07631; EMIHUDRAFT_106373.
DR GeneID; 17253797; -.
DR KEGG; ehx:EMIHUDRAFT_106373; -.
DR eggNOG; ENOG502RXG9; Eukaryota.
DR HOGENOM; CLU_331891_0_0_1; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd09171; PLDc_vPLD6_like; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR PANTHER; PTHR43856; CARDIOLIPIN HYDROLASE; 1.
DR PANTHER; PTHR43856:SF1; MITOCHONDRIAL CARDIOLIPIN HYDROLASE; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50035; PLD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 658..685
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 81017 MW; 9B6824BDD6035B7D CRC64;
MSDGPLQPGR EGSMSVCKGG PSALTRSTSR RRLPRWLHLP RRLYRPPTAA CATVPSHSGS
VAAAAASGAA AAIALLVAFI LFLCKRRRTA ARPAGGSGRR PLYRRASAST KLLELIHQTA
GRDESFPAKR LRREWGGGFT KGVLSAAKDS LFSLAPWRQS SRPHLPPGFE DAALSALQQR
PGAADAFEAL LRRLPAPSRE ALGRLRRCIL DLVVESDTAD SDTRLLFGAA DCLARLHTAY
LVPRPATRDA LFFPCDGSLD RLVRRLSASE SSIDAAVYTI TDERLTRLLL TGSFNWTVSA
HARGSCNLPQ SPAISRGNCE NLLVTSDSEM VSAFSAEFER LYSLFRASNA MPQQPLPRAA
AAARGGGGGG GGGGGGGGGG GGGAGGGGGG GGGGGGGGGG GTPHTLQRAA RRLGEVGRWA
GGSRSARRLP VGGAAGAAAP MAPPPSRPPA EWGARLSAGA RGVLRDYGAL RRDILAEEAV
GGAEREELLR AAAAEASDAF RGLLRRADPP ATAAGAATTA LIKGVAAHLH AAAAEGSGAG
GGGAGGDPGL VGVVEEELLQ PRPLAHEVLL FPSDEARQKL CSWIGSATTT LECCVFVISD
ARVAAELKEA AARGVAVRLI TDDKTALDGG SQVFGMASAG VETLVDPDYE LKSGAAPVPR
HMHHKYAIVD GRVLLCGSYN WSYSASARNN ENCVVTEDVY LVAKYSAEFE RLWREFKAAA
PLSQQQAAIR IQQIERGNRE RRRFAAMARS HRAANVFDVA RSAMDIASPG NRKRGRG
//
