ID R1F1D2_EMIHU Unreviewed; 721 AA.
AC R1F1D2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=FAD-binding PCMH-type domain-containing protein {ECO:0000259|PROSITE:PS51387};
GN ORFNames=EMIHUDRAFT_455985 {ECO:0000313|EMBL:EOD32705.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD32705.1};
RN [1] {ECO:0000313|EMBL:EOD32705.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD32705.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD32705}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB864497; EOD32705.1; -; Genomic_DNA.
DR RefSeq; XP_005785134.1; XM_005785077.1.
DR PaxDb; 2903-EOD32705; -.
DR EnsemblProtists; EOD32705; EOD32705; EMIHUDRAFT_455985.
DR GeneID; 17277977; -.
DR KEGG; ehx:EMIHUDRAFT_455985; -.
DR eggNOG; ENOG502SKRE; Eukaryota.
DR HOGENOM; CLU_335672_0_0_1; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.40.50.10310; Creatininase; 1.
DR InterPro; IPR024087; Creatininase-like_sf.
DR InterPro; IPR003785; Creatininase/forma_Hydrolase.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR35005:SF1; 2-AMINO-5-FORMYLAMINO-6-RIBOSYLAMINOPYRIMIDIN-4(3H)-ONE 5'-MONOPHOSPHATE DEFORMYLASE; 1.
DR PANTHER; PTHR35005; 3-DEHYDRO-SCYLLO-INOSOSE HYDROLASE; 1.
DR Pfam; PF02633; Creatininase; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF102215; Creatininase; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..122
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT REGION 415..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 75629 MW; 8EE02C397A9694C5 CRC64;
MSGLDKIESI DAEAGTIRCG AGVKLCDLED HARQHGWELR QHPSTRRTAS VGGFVAGGST
GHGALLHGGL SEDGAVLGLR VVTAEDQTPR VLELSGRDVF PVVHAYGTNG VITSVELPLA
RAQAWSDVTA AFPSLDAAAA FALDVANAPA VVKRGISVFQ APIAHKYLEA DALMHATGAD
APQWDSAHGR DGAMAAGGDA RHVAMVGPVE RLCAEHGGLT TRVVKATEAP RPMYEFGWNH
TTLHALRADK SVTYLQCVLE PSSALGLLRR VSGEFGPSEL LQHLEVVNFG GRAGFASLAL
LWPKGETGEA ANQRLREILS WHEANGIPVF DPHTHVLEDG GMKVTDWAQL GFKRRVDPHG
LLNPGKMRAW EEQSATADTS DPRGAFAASY RIADTSAVGG GPNVATSATA ADASSTAADS
FGTHASSPGS GRRRPRSRLW GEWSTADFAE ADLSQAVAVL PLGAVEAHGP HLPLGVDAMH
NADLLHRALA ALPEEALVLA MPPLDVGVSC EHAGFAGTLE LSAETAAAAW CELGACVARV
GIRKLVLYNS HGGNHALAEV VARRLRKRHG MLTVLAMNLG ASMAPGSACA NLFPEDEMRY
GLHGGALETS LMLHLRPQLV STSAAKDFAS RAAEQPKDAA LQLHAPGFAT KTGWLSQDLN
AHGVVGAAAT LSSAEKGATL ARECVESLRK LLVEVHAADV DELLSDRPLF PPQGDAGGEL
R
//
