ID R1IGA5_9PSEU Unreviewed; 521 AA.
AC R1IGA5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=H480_05734 {ECO:0000313|EMBL:EOD69474.1};
OS Amycolatopsis vancoresmycina DSM 44592.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1292037 {ECO:0000313|EMBL:EOD69474.1, ECO:0000313|Proteomes:UP000014139};
RN [1] {ECO:0000313|EMBL:EOD69474.1, ECO:0000313|Proteomes:UP000014139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44592 {ECO:0000313|EMBL:EOD69474.1,
RC ECO:0000313|Proteomes:UP000014139};
RA Kumar S., Kaur N., Kaur C., Raghava G.P.S., Mayilraj S.;
RT "Draft genome sequence of Amycolatopsis vancoresmycina strain DSM 44592T.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOD69474.1}.
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DR EMBL; AOUO01000060; EOD69474.1; -; Genomic_DNA.
DR RefSeq; WP_003062006.1; NZ_AOUO01000060.1.
DR AlphaFoldDB; R1IGA5; -.
DR PATRIC; fig|1292037.4.peg.1118; -.
DR eggNOG; COG3525; Bacteria.
DR OrthoDB; 9763537at2; -.
DR Proteomes; UP000014139; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06568; GH20_SpHex_like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..521
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004361769"
FT DOMAIN 37..167
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 171..485
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 333
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 521 AA; 56554 MW; 3410744B0DBE76E1 CRC64;
MHLSRAVLTA AVVSLAAVAV PTSAVAAPAA PERSVTDVVP VPVSAKPDPH GDFRLTPSTV
ITADRGAGQV ADYLRGLLRP ATGYPLPVVP HAAGLPAIAL QLGHDTRIGT EGYQLKVARD
GVTLKANTAD GLFEGVQSLR QLLPSAIEAK RVQHRTWTVA GGTILDYPRF AERGAMLDVA
RHFFRPDQVK LYLDQIAQYK VNTLHLHLAD DQGWRIEIKS WPKLATVGGK TAVDGDPGGY
YTQAQYQDIV AYAASRHITV IPEIDMPGHT NAAQSTYAEL NCDGKAVPVR TDTEVGYSSL
CISSPVTYKF VEDVVRELAA ITPGPYLHIG GDEAHSTPPA DYIAFEKKVQ PIVAKYGKKV
TGWHEIAKSD PPASAVPQYW DFGGDNASVA AAAARGSKIL MSPANFAYLD MKYTESTPLG
QDWAALVEVR DGYNWDPATL VNGVGESQVA GVEAPLWTET IRTSNDIEYM AFPRLPGIAE
IGWSPRSTHN WDAYRLRLAK QAPRWVQQGI DFYRSPQVDW K
//
