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Database: UniProt
Entry: R1IIP2_9PSEU
LinkDB: R1IIP2_9PSEU
Original site: R1IIP2_9PSEU 
ID   R1IIP2_9PSEU            Unreviewed;       403 AA.
AC   R1IIP2;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE            EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN   ORFNames=H480_01617 {ECO:0000313|EMBL:EOD70299.1};
OS   Amycolatopsis vancoresmycina DSM 44592.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=1292037 {ECO:0000313|EMBL:EOD70299.1, ECO:0000313|Proteomes:UP000014139};
RN   [1] {ECO:0000313|EMBL:EOD70299.1, ECO:0000313|Proteomes:UP000014139}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44592 {ECO:0000313|EMBL:EOD70299.1,
RC   ECO:0000313|Proteomes:UP000014139};
RA   Kumar S., Kaur N., Kaur C., Raghava G.P.S., Mayilraj S.;
RT   "Draft genome sequence of Amycolatopsis vancoresmycina strain DSM 44592T.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC       {ECO:0000256|ARBA:ARBA00004782}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOD70299.1}.
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DR   EMBL; AOUO01000018; EOD70299.1; -; Genomic_DNA.
DR   RefSeq; WP_003055948.1; NZ_AOUO01000018.1.
DR   AlphaFoldDB; R1IIP2; -.
DR   PATRIC; fig|1292037.4.peg.320; -.
DR   eggNOG; COG0179; Bacteria.
DR   OrthoDB; 3766879at2; -.
DR   UniPathway; UPA00139; UER00341.
DR   Proteomes; UP000014139; Unassembled WGS sequence.
DR   GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR   Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR   InterPro; IPR005959; Fumarylacetoacetase.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   InterPro; IPR015377; Fumarylacetoacetase_N.
DR   InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR   NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR   PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR   PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   Pfam; PF09298; FAA_hydrolase_N; 1.
DR   SUPFAM; SSF56529; FAH; 1.
DR   SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW   Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT   DOMAIN          18..110
FT                   /note="Fumarylacetoacetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09298"
FT   DOMAIN          118..401
FT                   /note="Fumarylacetoacetase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01557"
FT   REGION          164..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  43079 MW;  6462CA0E1188EFE1 CRC64;
     MNVTWLDLAD DTPFGLDNLP YGVFSAGGAP ERRIGVPVGD HVLDLTAAAA GTAAAFAPLL
     TGGVLNPLLA AGPATWRDVR ASVTEWLTER RYADQLRPHL VPLAEVTTHL AFDVADYVDF
     YSSEHHALNA GKIFRPDATE LPPNWKHLPI GYHGRAGTVV ASGTPVVRPH GQRKPRAADA
     PSFGPSQRLD IEAEVGFVVG VPSAPGTRVS TADFADHVFG VCLVNDWSAR DIQAWEYQPL
     GPFLGKSFAT SVSPWIVPLA ALEHARVDGP TQDPEPFEYL RTGEKWGLEL AMEVRLNGHL
     VSSPPFATQY WTAPQQLAHM TINGASLRTG DLFASGTVTG PERDQRGSFL ELSWGGREPF
     ELPGGVTRTF LEDGDEVVIS ATAPGPGGTR IGFGDVRGTV VAG
//
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