ID R2NUY8_9ENTE Unreviewed; 348 AA.
AC R2NUY8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=UAK_03682 {ECO:0000313|EMBL:EOH74818.1};
OS Enterococcus raffinosus ATCC 49464.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158602 {ECO:0000313|EMBL:EOH74818.1, ECO:0000313|Proteomes:UP000013877};
RN [1] {ECO:0000313|EMBL:EOH74818.1, ECO:0000313|Proteomes:UP000013877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49464 {ECO:0000313|EMBL:EOH74818.1,
RC ECO:0000313|Proteomes:UP000013877};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus raffinosus ATCC_49464.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOH74818.1}.
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DR EMBL; AJAL01000020; EOH74818.1; -; Genomic_DNA.
DR RefSeq; WP_010746846.1; NZ_KB946259.1.
DR AlphaFoldDB; R2NUY8; -.
DR PATRIC; fig|1158602.3.peg.3677; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_0_9; -.
DR OrthoDB; 9770238at2; -.
DR Proteomes; UP000013877; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR43401:SF2; L-THREONINE 3-DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..344
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 348 AA; 37795 MW; 65FB62DF5291BB84 CRC64;
MKAIQLLGKE KIQLSELAKP EIAEKEVLIK VRAASICGTD VRMYKNGYPT ASEETPLTLG
HEISGDIVEV GASVNFYKKG MRVAIAPNMG CGICDQCVSG NTHLCDSYEA FGINLPGGFA
EYLVIPEKAV RQGNISLIPD ALSYEEAALI EPFSCVFNGQ EIAGNKPGDH VLIIGSGPIG
IMHAMLARAR GAGKVMMNDL SESRLADAKK MIPDLIPLTS ENLQEKISAE TNHQGVDLCI
IAAPAPQAQE ASFNYMAMNG RCLFFGGLPK EKEEVKLNTN ILHYKQLRVF GCTRASLMGY
RTSAQLVASG RIPLKELITK RYSIDQFDEA LDNAKKAIGL KNVIVFKE
//
