ID R2REH6_9ENTE Unreviewed; 729 AA.
AC R2REH6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Penicillin-binding protein 2X {ECO:0000313|EMBL:EOH78996.1};
GN ORFNames=UAI_01642 {ECO:0000313|EMBL:EOH78996.1};
OS Enterococcus malodoratus ATCC 43197.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158601 {ECO:0000313|EMBL:EOH78996.1, ECO:0000313|Proteomes:UP000013783};
RN [1] {ECO:0000313|EMBL:EOH78996.1, ECO:0000313|Proteomes:UP000013783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43197 {ECO:0000313|EMBL:EOH78996.1,
RC ECO:0000313|Proteomes:UP000013783};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus malodoratus ATCC_43197.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOH78996.1}.
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DR EMBL; AJAK01000011; EOH78996.1; -; Genomic_DNA.
DR RefSeq; WP_010740487.1; NZ_KE136483.1.
DR AlphaFoldDB; R2REH6; -.
DR STRING; 71451.RV07_GL002491; -.
DR GeneID; 79787364; -.
DR PATRIC; fig|1158601.3.peg.1609; -.
DR eggNOG; COG0768; Bacteria.
DR OrthoDB; 9804124at2; -.
DR Proteomes; UP000013783; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 2.20.70.70; -; 1.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 672..729
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
SQ SEQUENCE 729 AA; 80591 MW; 9702B589FD533063 CRC64;
MSFKRLKRKI RKKNLTPMNN RKKVGVILFA TSIGLFFLFA VRMIYVVAGG HVAGTSLKAK
TEELYHGGQV VKAKRGTIYD RNGEVIAEDA TSYSVYAILS ESYVSGKEKL YAQEKNFDEL
ASILHKYLGI KEKSVLKTLK SGINSDGTSK YYQVEFGNKG KNISEETKQN IEDAMKKAKV
QGLYFTEHTD RMYPNGNFAS HFIGYAQPDK KEELVGMMGV EAAYDDVLKG KNGKVVYQKD
ENQRPIPGSV AEEKKAVNGE DIYTTLDAGL QSYLETLLDK VNSESKPTEM TATLMQAKTG
DILAMSQRPT FNPETKEGLG ESDAWRNFLI EDSYEPGSTM KVFTTAAAVN EGVFNENESY
MSGKIQVADA TINDWDLGKK GILTMRQALS WSSNVGMVKL EERLGDRWPE YVKRFGFGQS
TYSGLPGESK GTLPTSNIVD QAMSSYGQAI GVTNFQMMRG FTAVANDGKM LQPHYIEKVS
NPNTGKEIIT KPEVVGEPIT AETAQKVREY MRDTVESENY GSAYDQYKVP GYHISAKTGT
AQIASGGTYL TGDTNYIYSI ALMLPSEDPE YILYLTLKQP QENKEGILGE IANPLLTRAM
EFQNNTSDSS DEESNTKVTV EDYRNLSTSK AAADANKRGV TAVVVGDGEK VIKQSAKPGE
KVMANEHLIL LTDGKKEMPD VRGWSKADIL KLANLLDIDV TFKGDGYCTK QNIAPYAEVS
KKKLKITLG
//