ID R2XKT0_9ENTE Unreviewed; 668 AA.
AC R2XKT0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA methylase N-4/N-6 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=UKC_02722 {ECO:0000313|EMBL:EOI55514.1};
OS Enterococcus gilvus ATCC BAA-350.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158614 {ECO:0000313|EMBL:EOI55514.1, ECO:0000313|Proteomes:UP000013750};
RN [1] {ECO:0000313|EMBL:EOI55514.1, ECO:0000313|Proteomes:UP000013750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-350 {ECO:0000313|EMBL:EOI55514.1,
RC ECO:0000313|Proteomes:UP000013750};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus gilvus ATCC BAA-350.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOI55514.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJDQ01000008; EOI55514.1; -; Genomic_DNA.
DR RefSeq; WP_010781094.1; NZ_KB946874.1.
DR AlphaFoldDB; R2XKT0; -.
DR PATRIC; fig|1158614.3.peg.2717; -.
DR eggNOG; COG2189; Bacteria.
DR HOGENOM; CLU_029607_1_0_9; -.
DR OrthoDB; 9800801at2; -.
DR Proteomes; UP000013750; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR022221; TypeIII_RM_meth.
DR PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR Pfam; PF12564; TypeIII_RM_meth; 1.
DR PIRSF; PIRSF015855; TypeIII_Mtase_mKpnI; 1.
DR PRINTS; PR00506; D21N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 38..93
FT /note="Type III restriction/modification enzyme methylation
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF12564"
FT DOMAIN 195..521
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 668 AA; 77523 MW; D406014D16E614C0 CRC64;
MDTRLMKQIK DILKEFPQYW NGEELQRPIV IDDLKNYDAL LISALLKNQK IRENYSIKAG
DVVIFKVQEF IDILRYKDYW ADSYTKYSNN IGLSSEGKYL QYNTDVVLDF PYKDCVLEGG
MTKEDAGKEE VFYNEVIARD EIDTLLAPKA FVNVKKFDAE GEHEVDSFND KDNLIIKGNN
LLALHSLKER FSKKIKAVFI DPPYNTGGDS FKYNDRFNHS SWLTFMRNRL EVAKELLSED
GSLMMTIDYN ELSYLTVLTD EIFGRENLQN IITVKRSSAS GAKVINPGVV NVSDYLLIYS
KNKSMWKPNR IFAPKERDKR YNQFITNYDS DKEDWKYIPL LDAFSDKLKI KKSRLKTELG
DDYDNILNKF AYENADRIFR FVSLDDNQIS KATKDLKYLS KQNSDRLYHM ERDGYSDYYI
MNGQAMLFMK DRLISVDGEM RFGSALTEIW DDVLPNDLHN EGGVSFKKGK KTEKLVSRAI
ELTTNTDDYV LDFFGGSGTT GAVALKLKRK FIIIEQMNYI ESVTKTRMYK TVKGESTAGI
SKDVNWQGGG SFVYAELMEL NQLYMDKIDQ VSTKEELADL WNELDNNADL NFQLDKEKLV
YELLKENDEE EGSVTFNDLT FEEQKEIFKK ALDKNQLYVP YSEIEDKNVI ISDDDKAFNH
SFYSNEGE
//
