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Database: UniProt
Entry: R3GTH9_ENTFL
LinkDB: R3GTH9_ENTFL
Original site: R3GTH9_ENTFL 
ID   R3GTH9_ENTFL            Unreviewed;       453 AA.
AC   R3GTH9;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN   ORFNames=WOK_02553 {ECO:0000313|EMBL:EOJ96382.1};
OS   Enterococcus faecalis EnGen0359.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1169307 {ECO:0000313|EMBL:EOJ96382.1, ECO:0000313|Proteomes:UP000013601};
RN   [1] {ECO:0000313|EMBL:EOJ96382.1, ECO:0000313|Proteomes:UP000013601}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TR197 {ECO:0000313|EMBL:EOJ96382.1,
RC   ECO:0000313|Proteomes:UP000013601};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Enterococcus faecalis TR197.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOJ96382.1}.
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DR   EMBL; ASDV01000014; EOJ96382.1; -; Genomic_DNA.
DR   RefSeq; WP_002362548.1; NZ_KB944819.1.
DR   AlphaFoldDB; R3GTH9; -.
DR   SMR; R3GTH9; -.
DR   GeneID; 60894662; -.
DR   PATRIC; fig|1169307.3.peg.2549; -.
DR   HOGENOM; CLU_037408_2_2_9; -.
DR   Proteomes; UP000013601; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR   InterPro; IPR038076; MgtE_N_sf.
DR   InterPro; IPR006669; MgtE_transporter.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   NCBIfam; TIGR00400; mgtE; 1.
DR   PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR   PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01769; MgtE; 1.
DR   Pfam; PF03448; MgtE_N; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM00924; MgtE_N; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR   SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|RuleBase:RU362011};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW   Metal-binding {ECO:0000256|RuleBase:RU362011};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT   TRANSMEM        287..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        316..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        361..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        422..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   DOMAIN          142..205
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          206..262
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   453 AA;  50320 MW;  CDB202115B7BD54F CRC64;
     MNEGQEMEEQ FALLLETLKN QQMNEFRELF LALHIYEQGQ FYQSLDEKDR QHLYNYLSPK
     ELADMFDVIE EDNENMKDYL AEMRPSYAAD MLAEMYTDNA VDLLNMLDKS QKAKYLSLLS
     SEEAGEIKEL LHYEDETAGA IMTTEFVSIV ANQTVRSAMY VLKNQADMAE TIYYVYVVDQ
     ENHLVGVISL RDLIVNDDDT LIADILNERV ISVHVGDDQE DVAQTIRDYD FLAVPVTDYD
     DHLLGIVTVD DIIDVIDDEA ASDYSGLAGV DVEEVSENPL KAASKRLPWL ITLLFLGMST
     ASLISNYESL VSEASILAVF ISLITGTAGN AGTQSLAVAV RRLAMKDEKD SNFGRLILSE
     VLTGLVTGAV TGLTIMIVVG VWQHNLPLGF VIGMAMLCAI TVANLAGSLI PMLMDKLGFD
     PAVASGPFIT TLSDLTSVLI YFNIASMFMR YFV
//
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