ID R3WX54_9ENTE Unreviewed; 1015 AA.
AC R3WX54;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=type I site-specific deoxyribonuclease {ECO:0000256|ARBA:ARBA00012654};
DE EC=3.1.21.3 {ECO:0000256|ARBA:ARBA00012654};
GN ORFNames=UC7_01322 {ECO:0000313|EMBL:EOL46355.1};
OS Enterococcus caccae ATCC BAA-1240.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158612 {ECO:0000313|EMBL:EOL46355.1, ECO:0000313|Proteomes:UP000013840};
RN [1] {ECO:0000313|EMBL:EOL46355.1, ECO:0000313|Proteomes:UP000013840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1240 {ECO:0000313|EMBL:EOL46355.1,
RC ECO:0000313|Proteomes:UP000013840};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus caccae BAA-1240.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of DNA to give random double-stranded
CC fragments with terminal 5'-phosphates, ATP is simultaneously
CC hydrolyzed.; EC=3.1.21.3; Evidence={ECO:0000256|ARBA:ARBA00000851};
CC -!- SIMILARITY: Belongs to the HsdR family.
CC {ECO:0000256|ARBA:ARBA00008598}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOL46355.1}.
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DR EMBL; AJAU01000016; EOL46355.1; -; Genomic_DNA.
DR AlphaFoldDB; R3WX54; -.
DR STRING; 317735.RU98_GL002555; -.
DR PATRIC; fig|1158612.3.peg.1309; -.
DR eggNOG; COG0610; Bacteria.
DR Proteomes; UP000013840; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009035; F:type I site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1570.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007409; Restrct_endonuc_type1_HsdR_N.
DR InterPro; IPR040980; SWI2_SNF2.
DR PANTHER; PTHR42927; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42927:SF1; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF04313; HSDR_N; 1.
DR Pfam; PF18766; SWI2_SNF2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT DOMAIN 298..506
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT COILED 431..458
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1015 AA; 118222 MW; C75576176F3934E5 CRC64;
MLVENKEIRF EEDIETHLTK FGGWIKEKFR DSHFDPSKGI DLEKLITFIE KTQPKKWTRY
QTIYREDSKE KLLKRLEEEV STHGMLHVLR NGIKDRGVNL KVAQFKPVSG LNDTLQEKYE
ANIFTCTRQF AYSPNNNNTI DMVLSVNGIP LVALELKNQY TGQSVENAKV QFQKDRDPKE
LVFNFNRRFL VYFAVDHVDV YMTTRLSGKK TYFLPFNQGS NGPGIVGGKG NPANDDGYPT
SYLWEQVLQR DNLMDIIQRF MNLEIKKEKQ GTREITKQTL IFPRYHQLDV VRKLIADVKI
NKSGKNYLIQ HSAGSGKSNS IAWLAYHLAN VHDNDDQPIF TSTIIVTDRT VLDRQLQSTI
MSFDHKVGQV EIIDDKKTSQ DLKNAINDGR KIIITTLQKF PIIYQDIDEI SGQNFAVIVD
EAHTSQTGDS AKKLKTALAD KEATLKEYQE IEEEIENRTP DEQDKLVQTL VSQGQHSNLS
FFAFTATPKR ETLNMFGTKQ ADETFKPFHI YSMRQAIEEG FILDVLKNYM TYKTSYRIAK
EIEDNPELPK TEAVRAIARY QSFHPWVLRQ KTEVMIEQFR SVTKSAIGGK AKAMVVTPSR
LHAVRYMQEF KSYIEEKGYT DLDVLVAFSD SVEDDGEEYT ESKMNVTKDG ERIKESQLKE
AFHAEDFNIL IVAEKYQTGF DEPLLHTMFV DKRLKGVKAV QTLSRLNRTM FGKKDTFILD
FVNSEEEIVD AFQPFYEETT LENDININLI YDAQSKLRKY NVYSQEDINQ VMVLVRKAQT
KQDERLLGRI SSVFKPVINR YEELLNDTQY EFRVTMRSFI KWYNYISQLD RTFDMELLEE
SIFVSYLLSF IPKEQREKVS IEDKVKLEYY KLQENFSGEI SLIAEDSESG RLTNPEEINT
GIKPPDDRDS LEEIIHRINE RFPDDFTDSD RVLFENLYRS FTNDPDQKLV NMVKNNDAQM
FERSLFPDVF QEKIMTEYSH NQKAYEKLLG SDESYYRLVY SLLAKDLYKT LKTTV
//
