ID   R4GAM1_ANOCA            Unreviewed;      1102 AA.
AC   R4GAM1;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022322.2, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000022322.2, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000022322.2,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000022322.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; R4GAM1; -.
DR   STRING; 28377.ENSACAP00000022322; -.
DR   Ensembl; ENSACAT00000029739.2; ENSACAP00000022322.2; ENSACAG00000028909.2.
DR   eggNOG; KOG1075; Eukaryota.
DR   GeneTree; ENSGT00940000163630; -.
DR   HOGENOM; CLU_000680_1_1_1; -.
DR   InParanoid; R4GAM1; -.
DR   Proteomes; UP000001646; Chromosome 2.
DR   Bgee; ENSACAG00000028909; Expressed in adrenal gland and 9 other cell types or tissues.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR31635:SF196; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31635; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1102
FT                   /note="Reverse transcriptase domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5032299758"
FT   DOMAIN          463..742
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   1102 AA;  130827 MW;  FABBDA0A1BF247E0 CRC64;
     MQVTKMGWAK ALLLHYCFCQ WFKGQSNVPI ANQEAFLKNH HGRQVYESRG SNRARGVAIL
     IKNTKDFQVE MVKRDSDGRW VMIKGKIEKI RITLVCIYAP NKNQKKYLKK LFGEIDKFAQ
     GEVYCAGDYN LELVTTRQNS NRKLNIREYN MNDLLEGEPE NNRWTYYSGR HDTYSKIDYI
     LGKNTNQSVI LEAKTLPIHL SDHAPLRVKV KLEIERKERT WRYNTVLNSR EEEYETIRKE
     INKYFETNDN GQVTKDIIWD ASKAVIRGHC ISLEVNLRRR WRNEQDKRIK EIETLQDKHK
     RTKDRQIWRE LKEKKNQLEA FEERNIINKY LYVKSYSQSW NIKSMKRMAY YLKKKKEKTW
     IKRLKDENGK EQEEQSKIRE IMAKNNKNLY KEERVMQGNL NIREKIAEED RELLNQPITQ
     EETIRAIKGL KGGKSPGPDG FPAEYYKAFM EELAPHLTEL FNEIYTKQKV PLTWKVSEII
     TIPKKGRDLT QPGSYRPISL CNQDYKIFTK ILAKRLETIM PKIIKEDQYG FVKGRKIGDP
     IKNVVIAMNH ANSNKKKMGI LKLDVYKAFD KVNHNYLLRL CQQLNMGENF CKTLQQLYSN
     CKAKIRVNNG RTGEIPILNG TKQGCPLSPT LFVIAIEMLA ESIRNSTNWT GYKIEKGGGQ
     KEEIRLNFFA DDAMIITSQP LIMVKDIIKK LEEFKNISGL FVNIKKSEIL CLNTPPREQL
     EIRKISGLRL GLKKLKYLGV WIYKNPKSIV KGNYKQKWKV IEKQFKNWEG KTLTRVDRIR
     ALKMFIIPKL TYLFQTLPNT VDRKTLKTWD RRIRKWAVGG KRPRIRDKWL NAKEEEGGWG
     IPSLEVYHDA FQIQRLLEIQ YTKKKWANME KIINNTKEKE IIFREWSRRE EAEFKEPFKG
     TIKVWKKRKK KLSPGNENKM ATIWQINYNN NEIIGRTLRS IESRGKRLVE DLYTIDGDPV
     EQKEIQNWIG SGNWIQSWAI RQEIFRLREK IREQDSPFEK AIRKCLREEK KVAGDLYEQI
     ITVKEEIVEE IFQTWRMDME IEREDIQREI SNIAKEKYNV LREARRKMLQ KWYRTPAQLS
     RFLPGMKDRC WHGCEQRWCS IV
//