ID   R4GC18_ANOCA            Unreviewed;       322 AA.
AC   R4GC18;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Retinol dehydrogenase 12 {ECO:0008006|Google:ProtNLM};
GN   Name=LOC100557184 {ECO:0000313|Ensembl:ENSACAP00000022874.1};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022874.1, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000022874.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000022874.1};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000022874.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|RuleBase:RU000363}.
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DR   AlphaFoldDB; R4GC18; -.
DR   STRING; 28377.ENSACAP00000022874; -.
DR   Ensembl; ENSACAT00000030292.2; ENSACAP00000022874.1; ENSACAG00000005799.4.
DR   eggNOG; KOG1208; Eukaryota.
DR   GeneTree; ENSGT00940000158191; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000005799; Expressed in ovary and 12 other cell types or tissues.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR43157; PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43157:SF32; RETINOL DEHYDROGENASE 12; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..322
FT                   /note="Retinol dehydrogenase 12"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004372678"
SQ   SEQUENCE   322 AA;  35073 MW;  B25825F52DB9D717 CRC64;
     MQDFPGCALA LGLALALPLL GLLAAPYIRK YFAGGKCTST AKLNGKVVVI TGANTGIGKE
     TAKDLAGRGA RVILACRDMV KAEAAASEIR TKTGNQQVIA KKLDLADTKS IREFAENFLE
     EEKELHILIN NAGVMMCPYS KTADGFEMHF GVNHLGHFLL TFLLTECLKK SAPSRIVNVS
     SLAHHGGRIR FEDLQGEKSY QWGLAYCHSK LAGILFTREL ARRLQGTGVT VNALHPGTVA
     SDLPRHSTIM NFLWKLLPFL LKTPQEGAQT SVYCAVAEEL GSVSGKYFSD CKPAYVSPQG
     RDDETAKKLW DVSCELLGIQ WN
//