ID R4GCF5_ANOCA Unreviewed; 2199 AA.
AC R4GCF5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Dedicator of cytokinesis 10 {ECO:0000313|Ensembl:ENSACAP00000023019.2};
GN Name=DOCK10 {ECO:0000313|Ensembl:ENSACAP00000023019.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000023019.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000023019.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000023019.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000023019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_008104476.1; XM_008106269.2.
DR Ensembl; ENSACAT00000030439.2; ENSACAP00000023019.2; ENSACAG00000003851.4.
DR GeneID; 100565296; -.
DR CTD; 55619; -.
DR GeneTree; ENSGT00940000157469; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000003851; Expressed in adrenal gland and 11 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 194..303
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 684..862
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1702..2162
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1301..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2199 AA; 251997 MW; C6C522E606B3C817 CRC64;
MGCAASIVLL QAFRSVVQRN CAHICRRRQE ELSDEILPLD SDDEMSRPRT LIIMQEKPKL
LEPLDYEAVI AEIEKDVEND PLKDLILFPK DDFSIATVPW EIRTLYSSVS ENAEQKAEHL
FVKEACKYYS SQWHIVNYKY EQYSADFRHL PRNECRPEKL PSHSFEIDHE DVDKDEDTTS
HSSSKGGGGA GGTGVFKSGW LYKGNFNSTV NNSITVRSFK KRYFQLTQLS DNSYIMNFYK
DEKISKEPKG CIFLDSCTGV VQNNRLRKHA FELKMNDLTY FVLAAENEQD MDEWILTLNK
ILQINPEGCI QERKSADITD LKFDSEDLLT NYDCPPEETD SSENSLHPDF SKYLTETEET
VRASRNTDRL NLFSLDPDIS ALNPHRKDFT GTGSWLKPFE ERDTKRIMIM CKSLNLNLQA
CVSDNENDPI TNIEPFFVSV ALFDTKDNRK LSADFHVDLN HTVVRQMISN SSPSIENGTI
GIVGTKEEEP QVKGFPEEWL KYPKQAVFSI SNPHSEIVLV AKIEKVLMGN IAASAEPYIR
NPDSNKWAQK VLKSNKQFCS KLGKYRMPFA WSVRPVFKDN QGNIDRDSRF SPLFRQESSK
ISTDDLMKLV AEYRRADKIN KIQTIPGSLE ITVDCVPLEH PNCVTSSFIP VKPFNDIKEH
QPTVEVEEFV QESTKYSQTY RVYKNQIYIY PKHLKYDSQK CFNKARNITI CVEFKNSDEE
GAKPVRCIYG KPGGPPFTSA AYTAVLHHSQ NPDFYDEVKI ELPTQIHKKH HILFSFYHVT
CDINAKANAK KKEALETSVG YAWLPLLKED QLTSQEHNIP VATSLPPGYL SLQDPATGKH
SGNDIKWVDG GKPLFKVSSF VVSTIYTQDP YLNRFFQQCQ KRNRDLSQPP TSNFIISCKN
LLKIEKISVI VNFLPVILNQ LFWVLVQNKE DEVTTAVTRV LTDIVAKFHE EQLDQYIQSY
VKYVFKTKSF EERTIHEELA KNMTGLLKSN DQRTVKHVLK HSWFFFAIIL KSMAQHLVDT
NRIQIPRAQR FPESFLSELD TLIMILSDHV VWKYRDALEE TKNANHSVGG FLKRCFTFMD
RGFIFKLVNS YISMFGPGDH KILFQYKFDF LEEVCNHEHF IPLCLPIKSA NIPDSTTPSE
ATQQYRSSDI PEYTLTNEFC RKHFLIGLLL REVGWALQED QDIRHMALAV LKNLMAKHSF
DDRYTEREEQ AKIANLYMPL YGLLLDNMPR IYMKDMFLFN INTSNQGSRD DLSTAGGFQN
QAAMKHANSV DTSFSKDVLN SIAAFSSVAI STANHADSRG SLASLDSNPS TNEKNSEPTE
ACEKIARPLS LIGSALRFDK LDQAETRSLL MCFLQIMKTV SEDTLISYWQ RAPSTEITDF
FSILEVCLQN FRYLGKRNIV RKIAAAFKFA QTTQNNGTLK GSNSSCQASG LIPQWIHSAS
SSEVHRHHRS QTLPIIRGKN PFSNPKLLQI IDSTIASGSN ETDIVSYVDT EANIATEVCL
AILDLLCLYT QHHQRKLQQS DCQNTLMKKV FDTYLLFVQI NHSAAALKHV FAAMRLLVSK
FPSAFFQGQA DLCGSFCYEI LKCCNHRSRS TQTEASALLY FFMRKNFEFN KQKSIVRSHL
QLIKAVSQLI ADAGIGGSRF QHSLAITNNF ANGDKQMKNS NFPAEVKDLT KRIRTVLMAT
AQMKEHEKDP EMLVDLQYSL ANSYASTPEL RRTWLESMAK IHARNGDLSE AAMCYIHIAA
LIAEYLKRKG YWKMEKICTS RMLLEDDELS DSNVLLTTHT GGSLFSMGWP AFLNITPNIK
EEGAMKEDSG MQDTPYNENI LVEQLELCVD YLWKSERYEL IAEVNKPIIA VFEKQRDFKR
LSELYYDIHR SYLKVAEVVN SEKRLFGRYY RVAFYGQGFF EEEEGKEYIY KEPKLTGLSE
ISQRLLKLYA DKFGADNVKI IQDSNKVNPK DLDQKYAYIQ VTYVTPYFEE KESEERKTDF
EMHHNINRFV FETPFTLSGK KHGGVEEQCK RRTILTTSHL FPYVKKRIQV VSQTSTELNP
IEVAIDEMSK KISELNQLCT MEEVDMIRLQ LKLQGSVSVK VNAGPMAYAR AFLEETNAKK
YPDNQVKLLK EIFRQFAEAC GHALEVNERL IKEDQLEYQE EMKSHYKDML SELSEVMNEQ
ITCKEDSAKQ QGVEQPYSHV ISRTIAAPLG PVVSSNTDI
//
