ID R4GD10_ANOCA Unreviewed; 680 AA.
AC R4GD10;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Signal recognition particle subunit SRP72 {ECO:0000256|ARBA:ARBA00018350, ECO:0000256|PIRNR:PIRNR038922};
GN Name=SRP72 {ECO:0000313|Ensembl:ENSACAP00000023245.1};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000023245.1, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000023245.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000023245.1};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000023245.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER).
CC {ECO:0000256|PIRNR:PIRNR038922}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR038922}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}.
CC -!- SIMILARITY: Belongs to the SRP72 family.
CC {ECO:0000256|ARBA:ARBA00007676, ECO:0000256|PIRNR:PIRNR038922}.
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DR RefSeq; XP_003224711.1; XM_003224663.3.
DR AlphaFoldDB; R4GD10; -.
DR Ensembl; ENSACAT00000030664.2; ENSACAP00000023245.1; ENSACAG00000002381.4.
DR GeneID; 100564012; -.
DR KEGG; acs:100564012; -.
DR CTD; 6731; -.
DR GeneTree; ENSGT00390000013264; -.
DR HOGENOM; CLU_013808_1_0_1; -.
DR InParanoid; R4GD10; -.
DR OrthoDB; 91080at2759; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000002381; Expressed in forelimb bud and 13 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-UniRule.
DR GO; GO:0008312; F:7S RNA binding; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:0005047; F:signal recognition particle binding; IEA:Ensembl.
DR GO; GO:0030911; F:TPR domain binding; IEA:Ensembl.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR013699; Signal_recog_part_SRP72_RNA-bd.
DR InterPro; IPR026270; SRP72.
DR InterPro; IPR031545; SRP72_TPR-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14094; SIGNAL RECOGNITION PARTICLE 72; 1.
DR PANTHER; PTHR14094:SF9; SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72; 1.
DR Pfam; PF08492; SRP72; 1.
DR Pfam; PF17004; SRP_TPR_like; 1.
DR Pfam; PF13181; TPR_8; 2.
DR PIRSF; PIRSF038922; SRP72; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038922};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|PIRNR:PIRNR038922};
KW Signal recognition particle {ECO:0000256|ARBA:ARBA00023135,
KW ECO:0000256|PIRNR:PIRNR038922};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 234..267
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 539..596
FT /note="Signal recognition particle SRP72 subunit RNA-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF08492"
FT REGION 535..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..680
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 75138 MW; 0A6F66A3D5CC07C8 CRC64;
MAAGAGGGSG AGGAGAPSVA SLWSEVNRCG QSGDFGRALK SVNKILQISK DDATALHCKV
VCLIQNGSFK EALSVIHTHT KVLSSDSIAF EKAYCEYRLN RIENAMKTIE GVSQQTNKLK
ELYGQVLYRL ERYDDCLAVY RDLIRNSQDD YEEERKTNLS AVIAAQSTWE KVVPEDLGLQ
EGTYELSYNA ACAFIGQGKL NEAMKSLQKA EDLCRQSLSE DSDVTEEDIE AELAIIHGQM
AYIFQLQGHT EEALQLYNQI IKLKPTDVGL LAVIANNIIT INKDQNVFDS KKKVKLTNAE
GVEHKLSKKQ LQAIEFNKAL LAMFTNQADQ CHKLSSSLQS QSPEHLLPVL IQAAQLCREK
QHTKAIELLQ EFADQHPEKA AEIKLTMAQL KVAQGSVTKA CMILRSIEEL RHKPGMVSAL
VTMYSHEEDI DSAIEVLTQA IEWYQEFQPK SPVHLSLIRE AANFKLKHGR KKEAISDLEE
LWKQNPDDVH TLAQLISAYS LVDAEKAKVL SKHLPSSDAM SLKVDVDALE NSHGATYVRK
KGGKPTPENQ QKEQGQGDVK KKKKKKKGKL PKNYDPKVTP DPERWLPMRE RSYYRGRKKG
KKKDQIGKGT QGAMTTASSE LDASKTASSP PTSPRPGTVT AVPSASTANM IPPRHQKPVG
AAATKKKQQQ KKKKGGKGGW
//
