ID R4GIW1_CHICK Unreviewed; 312 AA.
AC R4GIW1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Transcription initiation factor TFIID subunit 8 {ECO:0000256|ARBA:ARBA00017307};
DE AltName: Full=TBP-associated factor 8 {ECO:0000256|ARBA:ARBA00031721};
GN Name=TAF8 {ECO:0000313|Ensembl:ENSGALP00010039603.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010039603.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010039603.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010039603.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF8 family.
CC {ECO:0000256|ARBA:ARBA00008767}.
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DR RefSeq; XP_015154440.1; XM_015298954.1.
DR AlphaFoldDB; R4GIW1; -.
DR Ensembl; ENSGALT00010064747.1; ENSGALP00010039603.1; ENSGALG00010026671.1.
DR GeneID; 419929; -.
DR CTD; 129685; -.
DR VEuPathDB; HostDB:geneid_419929; -.
DR GeneTree; ENSGT00390000017567; -.
DR OMA; SAHNYCE; -.
DR OrthoDB; 5483295at2759; -.
DR Proteomes; UP000000539; Chromosome 26.
DR Bgee; ENSGALG00000003498; Expressed in spleen and 13 other cell types or tissues.
DR ExpressionAtlas; R4GIW1; baseline and differential.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0001112; P:DNA-templated transcription open complex formation; IEA:Ensembl.
DR GO; GO:0051457; P:maintenance of protein location in nucleus; IEA:Ensembl.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045598; P:regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:Ensembl.
DR CDD; cd08049; TAF8; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR006565; BTP.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037818; TAF8.
DR InterPro; IPR019473; TFIID_su8_C.
DR PANTHER; PTHR46469; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8; 1.
DR PANTHER; PTHR46469:SF1; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8; 1.
DR Pfam; PF07524; Bromo_TP; 1.
DR Pfam; PF10406; TAF8_C; 1.
DR SMART; SM00576; BTP; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 34..111
FT /note="Bromodomain associated"
FT /evidence="ECO:0000259|SMART:SM00576"
SQ SEQUENCE 312 AA; 34715 MW; 7A94CCF72CBD336F CRC64;
MRIALYGSKM ADTAPGGSGT RSGSKHTTTP ADNYYLARRR TLQVVVSSLL TEAGFESAEK
AAVETLTEML QSYISEIGRS AKSYCEHTAR TQPTLSDIVV TLVEMGFNVE TLPAYAKRSQ
RMVITAPPVT NQPVTPKALT AGQNKPHPSH IPGYFPEFPD PHTYIKTPTY REPVSDYQVL
REKAASQRRD VERALTRFMA KTGETQSLFK DDVSTFPLIA ARPFTVPYLT ALLPSELEMQ
QMEETDSSEQ DDQTDTENLP LHISTDDSGP EKENASVLQQ NTSLSGSRNG EENMIDNPYL
RPVKKPKIRR KK
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