ID R4JA49_9REOV Unreviewed; 329 AA.
AC R4JA49;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=VP6 {ECO:0000313|EMBL:AGJ83559.1, ECO:0000313|EMBL:QPK39751.1};
OS Bluetongue virus 15.
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Sedoreoviridae; Orbivirus; Bluetongue virus.
OX NCBI_TaxID=35331 {ECO:0000313|EMBL:AGJ83559.1, ECO:0000313|Proteomes:UP000160890};
RN [1] {ECO:0000313|EMBL:AGJ83559.1, ECO:0000313|Proteomes:UP000160890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23/8/65 {ECO:0000313|EMBL:AGJ83559.1};
RA Koekemoer O., DeCastro M., Michuki G.;
RT "Genome sequences of bluetongue virus prototype strains.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKV61409.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=15RSArrrr/15 {ECO:0000313|EMBL:AKV61409.1};
RX PubMed=26252219;
RA Nomikou K., Hughes J., Wash R., Kellam P., Breard E., Zientara S.,
RA Palmarini M., Biek R., Mertens P.;
RT "Widespread Reassortment Shapes the Evolution and Epidemiology of
RT Bluetongue Virus following European Invasion.";
RL PLoS Pathog. 11:E1005056-E1005056(2015).
RN [3] {ECO:0000313|EMBL:QPK39751.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=15/Labstr/ZAF/1960/Howell_DVTD_S133_60
RC {ECO:0000313|EMBL:QPK39751.1};
RA Coetzee P., Guthrie A.J., Martin D., Venter E.H., Von Teichman B.,
RA Ebersohn K., Maclachlan J.N., Le Grange M., van Schalkwyk A.;
RT "Whole genome sequence characterization of bluetongue virus field and
RT vaccine strains from southern Africa.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Surrounds and interacts with the genomic dsRNA. Possesses
CC ss- and dsRNA-binding capacity. Its hydrophilic nature and capability
CC to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
CC {ECO:0000256|ARBA:ARBA00037248}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
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DR EMBL; JX272477; AGJ83559.1; -; Genomic_RNA.
DR EMBL; KP821828; AKV61409.1; -; Genomic_RNA.
DR EMBL; MT078347; QPK39751.1; -; Genomic_RNA.
DR Proteomes; UP000160890; Genome.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR001399; Orbi_VP6.
DR Pfam; PF01516; Orbi_VP6; 1.
DR PRINTS; PR00902; VP6CAPSID.
PE 4: Predicted;
FT REGION 26..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 35596 MW; 68888FF69E4C3F48 CRC64;
MSAAILLAPG DVIMRSSEEL KQRQIQINLV DWTESESEKE DKTESKKEDK AEESKDGEGT
QSESSQKKES GKEAKDADVD RRIHTTVGSG SSAKGSGERA NENVDGGDGK AGGGGRDVNA
GVGTTGANGG RWVVLTDEIA RAIESKYGTK IDVYRDEIPA QIIEVERSLQ KELGISREGV
AEQTERLRDL RRKEKSGTHA KAAEKGRRKQ GKRTQGDAQK EGTEEDKTSE EPASVGITIE
GVMSQKKLLS MIGGVERKMA PIGARESAVM LVSNSIKDVA RATAYFTAPT GDPHWKEVAR
EASKKKNILA YTSTGGDVKT EFLHLIDHL
//
