ID R4JTQ2_9PICO Unreviewed; 2207 AA.
AC R4JTQ2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS teschovirus A8.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Caphthovirinae; Teschovirus; Teschovirus A.
OX NCBI_TaxID=363168 {ECO:0000313|EMBL:AGK89513.1, ECO:0000313|Proteomes:UP000159322};
RN [1] {ECO:0000313|EMBL:AGK89513.1, ECO:0000313|Proteomes:UP000159322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fuyu/2009/2 {ECO:0000313|EMBL:AGK89513.1};
RA Zhang C., Cui S., Liu D., Ren X., Wang M.;
RT "Sequencing the complete genome of two porcine teschovirus-8 strains
RT isolated in China.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KC757344; AGK89513.1; -; Genomic_RNA.
DR Proteomes; UP000159322; Genome.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019030; C:icosahedral viral capsid; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR CDD; cd23212; Teschovirus_RdRp; 1.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 4.10.90.10; Capsid protein VP4 superfamily, Picornavirus; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR015031; Capsid_VP4_Picornavir.
DR InterPro; IPR037080; Capsid_VP4_sf_Picornavirus.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR022098; DUF3637.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF12337; DUF3637; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 3.
DR Pfam; PF00910; RNA_helicase; 1.
DR Pfam; PF08935; VP4_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022804};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 1036..1054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1502..1523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1203..1367
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1555..1744
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 1983..2095
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2207 AA; 247565 MW; 7AB045339CF99DA4 CRC64;
MECLKIFSLK PKNKNRSYSP RGVELKYNSD FAFKPRPLAP LLRLEPSDTR TRRIECAEVE
YDSWYPNPLD PTSLVCDVEL EMLQFQGTGS SRMENGNTNN SGNTGVINYN FYSNSYTDAV
DLSGAMSSQE SNAAENAASG PSSLLKAGIN AAARIGPLLA EPNFEEYKLS DRVDIIQKGT
STIITQNSVG SNTYTDCPKF DVSSVADEGT SGGPAVSRFV TLKAKSWTPS QPVYAFQAAH
LPYALIAQET PFKSLLSRHQ LMKCCWIVQV QVNTTRFHGG CLGVFAIPEF SVFSKLTGIS
VKYDNNKDGQ VSDIWDKFTN WYNPDMMYGA WYYSHVYDDT DKHWYKPTSQ QYGGVSPQSL
FCFPHQLINP RTNSSATLCL PFVDCGPITD VTVHCPWAIV VVVLRELTVA SGGTPSVDIN
VSVAPCEVEY HGLRQNSMYQ GPIPKIDIDA SKALFSSTQP YSAPPVYGKI PASNPAFMPG
EFFDYVQLAQ IPSLVKNREI RVTNSDRDAP IFHMPLRPTD TQTMNTMLGS VTRMFTQWRG
SIVVRCVFVG NQMQNCRILM AWTPQGFNAD YPTKMEDAMQ GHYVIYDTGV DSSADLVIPY
VAPYDFTPVR TPYTRTELPP TGNTSEVLVN TPYWSRGYIT IWQYTNLASP PGSPSQADFL
LFAFAGEDYV LKGPSNIIAS YQGNESSPLQ PAETGCDRAM TTSASNENPI PLAVENIGSS
RVDFFWDRYF HIATIPDVSN IRPQYLRLNI SDILSDPAIR QSLDATYMRC GLSIAVRVMP
ADTSSVNCMD ALTINMLYVP PGSSWAINKI DQTTPIENAE DSTHNYALPS FTWKPSQTPV
FTCSVPYVSF TTVLPTFYSG IESTSLIPKR NNQIPQDFGF GMLVLRPSMS PANKIVVSVW
VKFNNVRLYC PRPGIHDEES YSNESTRIPG AVTGRLSAAL TTMSLQGPGA TNFSLLKQAG
DIEENPGPSL SKLYQILKDP AVDALCEAYD ELKKFKEQAT NLLDSFSGDS ENLWLNKFIK
YLGYAILAWK SLHDPMTAAA VCFIIGSDIT AFVVSKLAKH LKKFAKTDPP PVPKPRACKK
EGCCCGNKHN YPDELNPFSE NGFWSRFKKG HLQGPMQDVS SLINILKGAE WIYHQFEKVI
KWLKTWRTAE YEVSSVFLQN EMKNYPHYHK KYKECANNYR HPDRAEVANY FQKMRKCAAH
VNPRLMGMFP EFDPSPPDPT RPEPVVVVLR GAPGQGKSVC SEMLARMLSY TLVGKSSYYA
FNSATKHFDG YKQQAVTIID DLGQDTSGED FRLFCQLVST TECIVPMADL PDKGMHFKSE
ILIANTNLPS FNPITVSDPA AIKRRIFLDL TVEANRAYAK PDGTLDLVRA LQSTGKESQS
PLFRQDHHIL YSDCVAFKHG RHTLSFLEVF DMIKRELQRR QNVSNSLTNL FTFQGPNDDS
WFTTFYKKWN LRAKENSEEK LILELIRYCH GSDMLKEYCQ LAAANKEKKT DYWNMVRIIE
EILAALTLIL SLISIMIVMY QLFFQGPYEA TATKPAKPNR QSLLKLVEMQ GPKGQANMEM
ERTLMKKNIV EMTYEKHNGK FQTTTVLFVR DRIFLINTHI LTGIKNFHYE NTEIPAASVQ
KVQAIFDGHP SDVTAVQFTV GRQYRDITGN FINSLPNPGT PIVGLMKTEG SSYMWSGECL
PFKNTMNTYE GCVPHVLPYK AVTAHGYCGS VMVADAGVWK GICGIHSLGD GAIGAATVLS
RQHLLNLLEG FLEFQGKIYD VQKADFVYTP TKTSLKPTFV CVDPKLEPAA LSHHDPRLKD
PENFKAVILS KHVGDSLQLP WGIRWASYKY AEKIRAMLPP DFLEPLSVRE AVEGIDGLDP
MDMDKSPGLP YVKKGLRRTD LWNPKTGPTI ELMAEINRYL DYNYDKHVFL TFLKDELRPK
EKVQAGKTRV IDVAGFGHAI VGRMLFGRLF AFFHKNPGWN TGSAVGVNPD LAWTQIFYTA
PSRNVLAMDY SGFDASHTSG MFCILKHFLT TLGYGTLQLS YIDSLCYSKH HWDDETYRLD
GGLPSGCSGT TIFNTIMNNI VARAAASYAA EGPVGILCYG DDILVSSPER FPVSDWLEFY
SKTPYKVTAA DKSEQIDWRD ITQCTFLKRG FVLDGSLVRP VMEEHHLAEL LKWARPGTLQ
AKLLSIAQLA FHLPRQAYDR LMLPFEEAGY EIPCHERLNE EWREMFI
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