ID R4KF52_9FIRM Unreviewed; 318 AA.
AC R4KF52;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component alpha subunit {ECO:0000313|EMBL:AGL00297.1};
GN ORFNames=Desgi_0742 {ECO:0000313|EMBL:AGL00297.1};
OS Desulfoscipio gibsoniae DSM 7213.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfoscipio.
OX NCBI_TaxID=767817 {ECO:0000313|EMBL:AGL00297.1, ECO:0000313|Proteomes:UP000013520};
RN [1] {ECO:0000313|EMBL:AGL00297.1, ECO:0000313|Proteomes:UP000013520}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7213 {ECO:0000313|EMBL:AGL00297.1,
RC ECO:0000313|Proteomes:UP000013520};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Parshina S.,
RA Plugge C., Muyzer G., Kuever J., Ivanova A., Nazina T., Klenk H.-P.,
RA Brambilla E., Spring S., Stams A.F., Woyke T.;
RT "Complete sequence of Desulfotomaculum gibsoniae DSM 7213.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP003273; AGL00297.1; -; Genomic_DNA.
DR RefSeq; WP_006520945.1; NC_021184.1.
DR AlphaFoldDB; R4KF52; -.
DR STRING; 767817.Desgi_0742; -.
DR KEGG; dgi:Desgi_0742; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_9; -.
DR OrthoDB; 9766715at2; -.
DR Proteomes; UP000013520; Chromosome.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:AGL00297.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000013520}.
FT DOMAIN 12..309
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 318 AA; 34955 MW; CBA39D612FB55065 CRC64;
MDNNEQKKLL RMMLLIRRFE EKLVDLSKDP QKLGGMMIVC TGQEAVAAGV GAALAPEDVI
ISNHRSHGHL LAKDAEPDLL MAEIFGRRTG YNKGKSGTLH IAAPEVNALC TTTVVGGGIP
IAVGTAFAAQ YQQKDFVTVC FFGNGASDEG SFHEALNMAS LWNLPVIFVC ENNIYSGAQR
LEEHTKVKDI ADRASAYAMR GEMVDGNDAL AVYEVVQKAR EDCLAGAGPV LIECKTYRWG
GHGTNDEQLY QPKDEIARWK EQCPIKKLKA SLMQAGTLAE QEYQDMEYEI RLIVERAVQF
AEASPWPDPA EALEDVYA
//
