ID R4MDF8_MYCTX Unreviewed; 968 AA.
AC R4MDF8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Transmembrane transport protein {ECO:0000313|EMBL:AGL25981.1};
GN ORFNames=J113_03610 {ECO:0000313|EMBL:AGL25981.1};
OS Mycobacterium tuberculosis CAS/NITR204.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1310114 {ECO:0000313|EMBL:AGL25981.1, ECO:0000313|Proteomes:UP000013548};
RN [1] {ECO:0000313|EMBL:AGL25981.1, ECO:0000313|Proteomes:UP000013548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAS/NITR204 {ECO:0000313|EMBL:AGL25981.1,
RC ECO:0000313|Proteomes:UP000013548};
RX PubMed=23788533;
RA Narayanan S., Deshpande U.;
RT "Whole-Genome Sequences of Four Clinical Isolates of Mycobacterium
RT tuberculosis from Tamil Nadu, South India.";
RL Genome Announc. 1:e00186-13(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP005386; AGL25981.1; -; Genomic_DNA.
DR AlphaFoldDB; R4MDF8; -.
DR KEGG; mtuc:J113_03610; -.
DR PATRIC; fig|1310114.3.peg.749; -.
DR HOGENOM; CLU_005108_3_2_11; -.
DR BioCyc; MTUB1310114:G13A2-527-MONOMER; -.
DR Proteomes; UP000013548; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..382
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 602..938
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 968 AA; 106183 MW; 8EB706578164E912 CRC64;
MSERHAALTS LPPILPRLIR RFAVVIVLLW LGFTAFVNLA VPQLEVVGKA HSVSMSPSDA
ASIQAIKRVG QVFGEFDSDN AVTIVLEGDQ PLGGDAHRFY SDLMRKLSAD TRHVAHIQDF
WGDPLTAAGS QSADDRAAYV VVYLVGNNET EAYDSVHAVR HMVDTTPPPH GVKAYVTGPA
ALNADQAEAG DKSIAKVTAI TSMVIAAMLL VIYRSVITAV LVLIMVGIDL GAIRGFIALL
ADHNIFSLST FATNLLVLMA IAASTDYAIF MLGRYHESRY AGEDRETAFY TMFHGTAHVI
LGSGLTIAGA MYCLSFARLP YFETLGAPIA IGMLVAVLAA LTLGPAVLTV GSFFKLFDPK
RRMNTRRWRR VGTAIVRWPG PVLAATCLVA SIGLLALPSY RTTYDLRKFM PASMPSNVGD
AAAGRHFSRA RLNPEVLLIE TDHDMRNPVD MLVLDKVAKN IYHSPGIEQV KAITRPLGTT
IKHTSIPFII SMQGVNSSEQ MEFMKDRIDD ILVQVAAMNT SIETMHRMYA LMGEVIDNTV
DMDHLTHDMS DITATLRDHL ADFEDFFRPI RSYFYWEKHC FDVPLCWSIR SIFDMFDSVD
QLSEKLEYLV KDMDILITLL PQMRAQMPPM ISAMTTMRDM MLIWHGTLGA FYKQQERNNK
DPGAMGRVFD AAQIDDSFYL PQSAFENPDF KRGLKMFLSP DGKAARFVIA LEGDPATPEG
ISRVEPIKRE AREAIKGTPL QGAAIYLGGT AATFKDIREG ARYDLLIAGV AAISLILIIM
MIITRSVVAA VVIVGTVVLS MGASFGLSVL VWQDILGIEL YWMVLAMSVI LLLAVGSDYN
LLLISRLKEE IGAGLNTGII RAMAGTGGVV TAAGMVFAVT MSLFVFSDLR IIGQIGTTIG
LGLLFDTLVV RSFMTPSIAA LLGRWFWWPL RVRPRPASQM LRPFAPRRLV RALLLPSGQH
PSATGAHE
//
