GenomeNet

Database: UniProt
Entry: R4U2J9_9MOLU
LinkDB: R4U2J9_9MOLU
Original site: R4U2J9_9MOLU 
ID   R4U2J9_9MOLU            Unreviewed;       450 AA.
AC   R4U2J9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AGM25597.1};
GN   ORFNames=SSYRP_v1c00010 {ECO:0000313|EMBL:AGM25597.1};
OS   Spiroplasma syrphidicola EA-1.
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales;
OC   Spiroplasmataceae; Spiroplasma.
OX   NCBI_TaxID=1276229 {ECO:0000313|EMBL:AGM25597.1, ECO:0000313|Proteomes:UP000013963};
RN   [1] {ECO:0000313|EMBL:AGM25597.1, ECO:0000313|Proteomes:UP000013963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EA-1 {ECO:0000313|EMBL:AGM25597.1};
RX   PubMed=23711669; DOI=10.1093/gbe/evt084;
RA   Ku C., Lo W.S., Chen L.L., Kuo C.H.;
RT   "Complete genomes of two dipteran-associated spiroplasmas provided
RT   insights into the origin, dynamics, and impacts of viral invasion in
RT   spiroplasma.";
RL   Genome Biol. Evol. 5:1151-1164(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP005078; AGM25597.1; -; Genomic_DNA.
DR   RefSeq; WP_016340259.1; NC_021284.1.
DR   EnsemblBacteria; AGM25597; AGM25597; SSYRP_v1c00010.
DR   KEGG; ssyr:SSYRP_v1c00010; -.
DR   PATRIC; fig|1276229.3.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000013963; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000013963};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013963}.
FT   DOMAIN      138    271       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      357    426       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     146    153       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51660 MW;  95E709B8EEA70DBB CRC64;
     MNTKELWTEV KEILARDESI PPEIYNYYIS DTNLYTVSDN NCLITTKSEI AIGVFEAGLK
     DKITQILKSL TGIEYHTSFE LEQNINKNPI VANNVDTLNN AQKTIYYENY TFENFVSGDS
     NQEALQAALA VAQDLGNKWN PLFIYGDSGL GKTHLLYAIK NKVEEFYDGE LKVKYLRADE
     FGKIAMDILN QGHQVIEAFK TSYDQYDCLM IDDIQLLAKR NKTNEIFFYI FNSYIEKNKQ
     IVITSDKYPD DLGGFEARII SRFSYGLSIG LDSPDFETAL KILEQKLKQQ RNLSLFSEEA
     LEFIALNFNS DVRKLEGAIK RLLFFAVMNK KPDEIITLKD VEKSFKDAPL QNNEKITSKK
     IKQVIADNYN ITIKAMMSKT RVSNVMQARQ LAMYFCRTLL DDPFTRIGAE FGGKDHTTVM
     NSVKKVENQI ATNKEFKYFV NSIRKKIEGK
//
DBGET integrated database retrieval system