ID R4U467_9MOLU Unreviewed; 386 AA.
AC R4U467;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Tagatose-6-phosphate ketose/aldose isomerase {ECO:0000313|EMBL:AGM26242.1};
GN Name=agaS {ECO:0000313|EMBL:AGM26242.1};
GN ORFNames=SSYRP_v1c06520 {ECO:0000313|EMBL:AGM26242.1};
OS Spiroplasma syrphidicola EA-1.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=1276229 {ECO:0000313|EMBL:AGM26242.1, ECO:0000313|Proteomes:UP000013963};
RN [1] {ECO:0000313|EMBL:AGM26242.1, ECO:0000313|Proteomes:UP000013963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EA-1 {ECO:0000313|EMBL:AGM26242.1};
RX PubMed=23711669; DOI=10.1093/gbe/evt084;
RA Ku C., Lo W.S., Chen L.L., Kuo C.H.;
RT "Complete genomes of two dipteran-associated spiroplasmas provided insights
RT into the origin, dynamics, and impacts of viral invasion in spiroplasma.";
RL Genome Biol. Evol. 5:1151-1164(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-
CC phosphate + NH4(+); Xref=Rhea:RHEA:47680, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:71674, ChEBI:CHEBI:138150;
CC Evidence={ECO:0000256|ARBA:ARBA00029292};
CC -!- SIMILARITY: Belongs to the SIS family. AgaS subfamily.
CC {ECO:0000256|ARBA:ARBA00007748}.
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DR EMBL; CP005078; AGM26242.1; -; Genomic_DNA.
DR RefSeq; WP_016340886.1; NC_021284.1.
DR AlphaFoldDB; R4U467; -.
DR STRING; 1276229.SSYRP_v1c06520; -.
DR KEGG; ssyr:SSYRP_v1c06520; -.
DR PATRIC; fig|1276229.3.peg.647; -.
DR eggNOG; COG2222; Bacteria.
DR HOGENOM; CLU_012520_0_0_14; -.
DR OrthoDB; 9779207at2; -.
DR Proteomes; UP000013963; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR CDD; cd05010; SIS_AgaS_like; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035464; SIS_AgaS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR32502:SF3; D-GALACTOSAMINE-6-PHOSPHATE DEAMINASE AGAS-RELATED; 1.
DR PANTHER; PTHR32502; N-ACETYLGALACTOSAMINE PERMEASE II COMPONENT-RELATED; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:AGM26242.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000013963};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 46..205
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 386 AA; 43175 MW; 9A08B965ECBE6E85 CRC64;
MIFGLNQQDL KEMGSIYTAQ EIFQQPKVWS EVIALVAKET KKIKTFLSRF DLKKIKIIFT
GSGSSEFAGI ILADYLRLRG YDAISNAATD IVSNPAVYFD NSEEPLILIS FARSGNSPES
LGAINLAEQI VPNLFQIIIT CNNEGQLYQK NKNNEKILSL LLPPATNDQS FAMTSSFTSM
LLTVFLIFHQ DDSSVKNELI DLITKTEKFL NENYRQIVAL AQIPAERVVF LGSNILKGYA
QEASLKLLEL TNGKVVSTFN TALGFRHGPK AIITPNTTVF FFVSQDKYTR QYDLDLLKEL
YHDNIAGEII VFDSIIDKAI MTYCNKYLPC ALAASNDVIS GLQAIVWAQI YALFTALQFK
ITPDNPCPTG QINRVVKGVK IHPWKK
//
