ID R4UC84_9MOLU Unreviewed; 262 AA.
AC R4UC84;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=dam {ECO:0000313|EMBL:AGM25509.1};
GN ORFNames=SCHRY_v1c09360 {ECO:0000313|EMBL:AGM25509.1};
OS Spiroplasma chrysopicola DF-1.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=1276227 {ECO:0000313|EMBL:AGM25509.1, ECO:0000313|Proteomes:UP000013964};
RN [1] {ECO:0000313|EMBL:AGM25509.1, ECO:0000313|Proteomes:UP000013964}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DF-1 {ECO:0000313|EMBL:AGM25509.1};
RX PubMed=23711669; DOI=10.1093/gbe/evt084;
RA Ku C., Lo W.S., Chen L.L., Kuo C.H.;
RT "Complete genomes of two dipteran-associated spiroplasmas provided insights
RT into the origin, dynamics, and impacts of viral invasion in spiroplasma.";
RL Genome Biol. Evol. 5:1151-1164(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP005077; AGM25509.1; -; Genomic_DNA.
DR RefSeq; WP_016339330.1; NC_021280.1.
DR AlphaFoldDB; R4UC84; -.
DR STRING; 1276227.SCHRY_v1c09360; -.
DR REBASE; 64917; M2.SchDF1ORF9340P.
DR KEGG; scr:SCHRY_v1c09360; -.
DR PATRIC; fig|1276227.3.peg.941; -.
DR eggNOG; COG0338; Bacteria.
DR HOGENOM; CLU_1061326_0_0_14; -.
DR Proteomes; UP000013964; Chromosome.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR012327; MeTrfase_D12.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR30481; DNA ADENINE METHYLASE; 1.
DR Pfam; PF02086; MethyltransfD12; 1.
DR PRINTS; PR00505; D12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:AGM25509.1};
KW Transferase {ECO:0000313|EMBL:AGM25509.1}.
SQ SEQUENCE 262 AA; 31235 MW; 4DC9FC22ECD9AB73 CRC64;
MKFISPLTWP GGKAKHFDKI KSFLPGNFDM FIDLFCGGAS VGLNVLDQNL CNQVILNDLH
TELISFWQEG IHLIELNYLK TLAYPNSKTI SEMKLKLANN YCLNQGEKFL LKNALTFNGK
EWGTWTDKRL QQNFNTNKLI RVQNVRKLLV HPNYDIKFFN FDYKVMINRY GNNENIIWYL
DPPYYYNKGK PYKHSKINFE ELKTWIMKIK GKWIMSIDNS DFIKELFKEF NIYEFEWFYS
STNCHNRKPK LGKELIITNF RK
//
