ID R4UI21_9MOLU Unreviewed; 320 AA.
AC R4UI21;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=GMP reductase {ECO:0000256|ARBA:ARBA00015800};
DE EC=1.7.1.7 {ECO:0000256|ARBA:ARBA00012678};
DE AltName: Full=Guanosine 5'-monophosphate oxidoreductase {ECO:0000256|ARBA:ARBA00030699};
GN Name=guaC {ECO:0000313|EMBL:AGM24966.1};
GN ORFNames=SCHRY_v1c03830 {ECO:0000313|EMBL:AGM24966.1};
OS Spiroplasma chrysopicola DF-1.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=1276227 {ECO:0000313|EMBL:AGM24966.1, ECO:0000313|Proteomes:UP000013964};
RN [1] {ECO:0000313|EMBL:AGM24966.1, ECO:0000313|Proteomes:UP000013964}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DF-1 {ECO:0000313|EMBL:AGM24966.1};
RX PubMed=23711669; DOI=10.1093/gbe/evt084;
RA Ku C., Lo W.S., Chen L.L., Kuo C.H.;
RT "Complete genomes of two dipteran-associated spiroplasmas provided insights
RT into the origin, dynamics, and impacts of viral invasion in spiroplasma.";
RL Genome Biol. Evol. 5:1151-1164(2013).
CC -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP
CC to IMP. It functions in the conversion of nucleobase, nucleoside and
CC nucleotide derivatives of G to A nucleotides, and in maintaining the
CC intracellular balance of A and G nucleotides.
CC {ECO:0000256|ARBA:ARBA00037691}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH;
CC Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115,
CC ChEBI:CHEBI:58349; EC=1.7.1.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000930};
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DR EMBL; CP005077; AGM24966.1; -; Genomic_DNA.
DR RefSeq; WP_016338791.1; NC_021280.1.
DR AlphaFoldDB; R4UI21; -.
DR STRING; 1276227.SCHRY_v1c03830; -.
DR KEGG; scr:SCHRY_v1c03830; -.
DR PATRIC; fig|1276227.3.peg.383; -.
DR eggNOG; COG0516; Bacteria.
DR HOGENOM; CLU_022552_5_0_14; -.
DR OrthoDB; 9805398at2; -.
DR Proteomes; UP000013964; Chromosome.
DR GO; GO:1902560; C:GMP reductase complex; IEA:InterPro.
DR GO; GO:0003920; F:GMP reductase activity; IEA:InterPro.
DR GO; GO:0006163; P:purine nucleotide metabolic process; IEA:InterPro.
DR CDD; cd00381; IMPDH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_01511; GMP_reduct_type2; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005994; GuaC_type_2.
DR InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR InterPro; IPR001093; IMP_DH_GMPRt.
DR NCBIfam; TIGR01306; GMP_reduct_2; 1.
DR PANTHER; PTHR43170; GMP REDUCTASE; 1.
DR PANTHER; PTHR43170:SF5; GMP REDUCTASE; 1.
DR Pfam; PF00478; IMPDH; 1.
DR PIRSF; PIRSF036500; GMP_red_Firmic; 1.
DR SMART; SM01240; IMPDH; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR PROSITE; PS00487; IMP_DH_GMP_RED; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 4..309
FT /note="IMP dehydrogenase/GMP reductase"
FT /evidence="ECO:0000259|Pfam:PF00478"
SQ SEQUENCE 320 AA; 35428 MW; 7F06DC1CB3BDA63C CRC64;
MKAFDYEDIQ LIPELCIVQS RSECNTKVKL GKHTFNLPVV PSNMATVVNE ELCQKLAGKN
YFYIMHRFNV DQVKFVRNMK GKNLITSISV GVKPEDYQLV STLKAENLIP DYITIDIAHG
HAFSVRDMID HIRKEMGKDV FIIAGNVGTP KAVRDLEQWG ADATKVGIGP GKVCITKLKT
GFGTGGWQLS AVKWCSKGSS KPIIADGGIR VNGDIAKSIR MGATFCMVGS LFAAHQESPG
SQVEENGIQY KEYFGSASEY NKSEKRYVEG KKELIEIRGS IFETLQEMTE DLQSSISYAG
GTDVEAIKKV DYVILKDSNF
//
