ID R4WIN5_9AQUI Unreviewed; 281 AA.
AC R4WIN5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:BAN18796.1};
OS Persephonella sp. MT-13.
OC Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC Persephonella.
OX NCBI_TaxID=1275015 {ECO:0000313|EMBL:BAN18796.1};
RN [1] {ECO:0000313|EMBL:BAN18796.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MT-13 {ECO:0000313|EMBL:BAN18796.1};
RX PubMed=23630523; DOI=10.3389/fmicb.2013.00107;
RA Mino S., Makita H., Toki T., Miyazaki J., Kato S., Watanabe H., Imachi H.,
RA Watsuji T., Nunoura T., Kojima S., Sawabe T., Takai K., Nakagawa S.;
RT "Biogeography of Persephonella in deep-sea hydrothermal vents of the
RT Western Pacific.";
RL Front. Microbiol. 4:107-107(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; AB774023; BAN18796.1; -; Genomic_DNA.
DR AlphaFoldDB; R4WIN5; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 230..281
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAN18796.1"
FT NON_TER 281
FT /evidence="ECO:0000313|EMBL:BAN18796.1"
SQ SEQUENCE 281 AA; 31631 MW; CFDE3FFCFB1A30E0 CRC64;
KRLRELAFLN PGVRFLCADR RKDIEEEFLY HEGIKDFVRV LNQAKDPLFS EIIYVKEEKE
RIIVEVAFQY TKSYNEVIES FVNNVKTVEG GTHVAGFRAA LTRAMNKTLS GMRLPKELKG
GIKGEDLREG LTAVISVKVP EPQFEGQTKS KLGNQEVKKV VETVVGDYLL DYFEKNKDIA
LKIAEKAIEA AVAREAARKA KEISRRKSFL EDTTLPGKLA DCSETDPEKC ELFIVEGESA
GGSAKQGRDR RTQAILPLKG KILNVEKARI DKILSNEEIR S
//
