ID R4X8H2_TAPDE Unreviewed; 1524 AA.
AC R4X8H2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=TAPDE_001258 {ECO:0000313|EMBL:CCG81606.1};
OS Taphrina deformans (strain PYCC 5710 / ATCC 11124 / CBS 356.35 / IMI 108563
OS / JCM 9778 / NBRC 8474) (Peach leaf curl fungus) (Lalaria deformans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Taphrinomycetes;
OC Taphrinales; Taphrinaceae; Taphrina.
OX NCBI_TaxID=1097556 {ECO:0000313|EMBL:CCG81606.1, ECO:0000313|Proteomes:UP000013776};
RN [1] {ECO:0000313|EMBL:CCG81606.1, ECO:0000313|Proteomes:UP000013776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PYCC 5710 / ATCC 11124 / CBS 356.35 / IMI 108563 / JCM 9778 /
RC NBRC 8474 {ECO:0000313|Proteomes:UP000013776};
RX PubMed=23631913; DOI=10.1128/mBio.00055-13;
RA Cisse O.H., Almeida J.M.G.C.F., Fonseca A., Kumar A.A., Salojaervi J.,
RA Overmyer K., Hauser P.M., Pagni M.;
RT "Genome sequencing of the plant pathogen Taphrina deformans, the causal
RT agent of peach leaf curl.";
RL MBio 4:e00055-e00013(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCG81606.1}.
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DR EMBL; CAHR02000046; CCG81606.1; -; Genomic_DNA.
DR STRING; 1097556.R4X8H2; -.
DR VEuPathDB; FungiDB:TAPDE_001258; -.
DR eggNOG; KOG1240; Eukaryota.
DR Proteomes; UP000013776; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:InterPro.
DR GO; GO:0016236; P:macroautophagy; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13980; STKc_Vps15; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000013776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 24..301
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 425..456
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1103..1135
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 784..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1465..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1524 AA; 171796 MW; 55F359E04ABF60F8 CRC64;
MGNNNSTISN AATLDSYIGE LHDLSFVKSL SSSRFLKCVL GKHIDGQVVV KLFVKSNIVN
LQEYIRQSEV ENDQLLDIPN ALSYQRLQET DRAVYLVRQY IASNLYDRVS TRPFLEAVEK
RWIVFQLLTG LQDCHARGIR HGDIKTENVL VTSWNWVYLT DFAFFKPTYL PENNPADFSY
FFDTSFRRTC YIAPERFHTA SEPKKGPVTD AMDIFSLGCV IAELFLEGIS LFDLSQMLRY
KAGEYDPKFL LDKINDLEIR SLIGHMINID PDQRYSAEKY LQKWQRRAFP HYFTTFMHEY
LSLVTEPQRH HVQVPSRDID DSLDRIFFEF DKVSFFLKFD DTDDKQHASL DGRQERANLL
SIPNYRRIHN NKIDRAESDN GALVFLSILL TGLRNTTRTA SRIRACETIV ALSDKISDEA
KLDRVVPFFV DLLTDDAPEV RSNALWSLAE VLSRVTILTP VNAFIFSDYI LPKITNAVFA
SSSLVRVKYA QCITTIIRSA ERFYDMAHAL CHEGFLTFSS PKSDVEVDEK HQYNYHLRSG
KADQTKLLEN HLVRLLTDPS TAVKRALLPH IVDLTTFFGP HRGIDLLLGH LISYLNDRDW
LLRIAFFDHV VPLGQYLGQR AVETYIVPVM IQALVDSEDF IVEKVLNSLA SLCSAGLIGH
PSSTSVCALI VRFLIHPNLW IREAATNYVA IICKSLTPAD LYSIVYPLVK PFLRMEVMFL
TPVAILQSLK RPLSQQALDI ATKWAMETPK DKASYWTTNS LQRDFSGDTT SIAPYQNLPI
LSENSSRRSL SSPVKIKPAR PAERTMGLRT QEDEYSMSRL RDTGLKPEDD WKLTALREYI
YRRSKQKKEQ ELLQQEQYKV QETPRPITIF FDDLVQEIVI PEYQRSKHNA AHDVHTALRD
ASYNLESNRA RRSASRTMSN IKSVTSTAPV VANKLRPPNN ILNSATSTIA APITQTGAAE
LNLHKVITNE SASGSKASSI NGESKALSLR ASSAVNLPGM STKAQAEVST TNTVVLGQVD
HQCLDLPETG TTRKTSRRSE APTASHSYNG FDESVINMLE KTYVNSLSNT VEVIENGAKL
TPARARVAPE GSWKDEVVLV AHVQEHIAAI NCVRVAPDHT FFVTCSDDGT IKLWESGKLE
RNVTNRARHT YRGLAGSKVK CVTFLENSYC IAAASDQGII HVIECKQAQT HGSEAKGMKF
LKSYDLPPQE NVLEMIHVMQ DQVSTLLVTT TKSRILAIDL QKMCLSYALQ NPVHHGTISS
LCTNDRKTWL LLGTSRGILD LWDLRFRLKV KSIGLPTAGK VNDLCLHPCR GGGRWVCVVT
AGSTEITVWD IEKSVCREVY RPFGYPGTAT LDNYKVWNVE ESKPEELLAK FTHEIALESS
QSRLRTSGRV LISAGNVYKS SQSSSTSQNR PDVSLICAST DRMVRRWDLY KVEQSSVIST
IHRDAEQMSY QATTSGNLVI NEEVASKSSS RSKSKSARLP SNSPLKQNEH LKAHMDIILD
LACLQWPYKM LISVDRSGVL KVFA
//
