ID R4Z5L4_9ACTN Unreviewed; 473 AA.
AC R4Z5L4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Medium chain aldehyde dehydrogenase {ECO:0000313|EMBL:CCM64626.1};
GN Name=ydcW {ECO:0000313|EMBL:CCM64626.1};
GN ORFNames=BN381_430022 {ECO:0000313|EMBL:CCM64626.1};
OS Candidatus Microthrix parvicella RN1.
OC Bacteria; Actinomycetota; Acidimicrobiia; Acidimicrobiales;
OC Microthrixaceae; Microthrix.
OX NCBI_TaxID=1229780 {ECO:0000313|EMBL:CCM64626.1, ECO:0000313|Proteomes:UP000018291};
RN [1] {ECO:0000313|EMBL:CCM64626.1, ECO:0000313|Proteomes:UP000018291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RN1 {ECO:0000313|EMBL:CCM64626.1,
RC ECO:0000313|Proteomes:UP000018291};
RX PubMed=23446830; DOI=10.1038/ismej.2013.6;
RA Jon McIlroy S., Kristiansen R., Albertsen M., Michael Karst S.,
RA Rossetti S., Lund Nielsen J., Tandoi V., James Seviour R., Nielsen P.H.;
RT "Metabolic model for the filamentous 'Candidatus Microthrix parvicella'
RT based on genomic and metagenomic analyses.";
RL ISME J. 7:1161-1172(2013).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCM64626.1}.
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DR EMBL; CANL01000038; CCM64626.1; -; Genomic_DNA.
DR RefSeq; WP_012228840.1; NZ_HG422565.1.
DR AlphaFoldDB; R4Z5L4; -.
DR STRING; 1229780.BN381_430022; -.
DR GeneID; 78314419; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_2_11; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000018291; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07092; ALDH_ABALDH-YdcW; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR015657; Aminobutyraldehyde_DH.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR11699:SF307; GAMMA-AMINOBUTYRALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000018291}.
FT DOMAIN 11..469
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 246
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 473 AA; 50248 MW; 8981FF59EA5AADFB CRC64;
MAMQNYIGGE WRDAASRGTD EVLNPATGEC ITEVAASDAD DVDAAVAAAT DAFVSWGRTS
PRERSEKLLA LADAVEDNLD ELKRLEMENV GKPTSIIEFE FDLTVDNLRF FAGAARTMNT
QAAGEYIEDH TSMLRRDPLG VCAGIAPWNY PLNMAVWKLG PALAAGNTFI LKPSELTPMT
ALKLAEISAD IFPPGVFNVV TGQGETAGDA LVKHPGVAMV SITGDVDTGK LIARNAADSL
KRVHLELGGK APVVVFDDAD LETLVATLAE TGYYNSGQDC TAPCRVVAGP RIYDDLVAGL
SSAVGDLVTG DPMDEATAVG PLVSAGQQAR VAGMVGRAVE GGAEVTVGGD TLDRAGFFYA
PTVVANPAQD AEIVQREVFG PVISVQRFSD DDQALAWANG VNYGLAASVW TSDVSRAMRM
SAHLRFGTVW VNDHIPIVSE MPHGGFKQSG YGKDMSIYAV EHYTELKHVM VKF
//
