ID   R5BKT0_9FIRM            Unreviewed;       561 AA.
AC   R5BKT0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Glycosyl hydrolase family 2 TIM barrel domain protein {ECO:0000313|EMBL:CCX53402.1};
GN   ORFNames=BN814_00998 {ECO:0000313|EMBL:CCX53402.1};
OS   Veillonella sp. CAG:933.
OC   Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC   Veillonella.
OX   NCBI_TaxID=1262980 {ECO:0000313|EMBL:CCX53402.1, ECO:0000313|Proteomes:UP000018347};
RN   [1] {ECO:0000313|EMBL:CCX53402.1, ECO:0000313|Proteomes:UP000018347}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:933 {ECO:0000313|Proteomes:UP000018347};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCX53402.1}.
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DR   EMBL; CAWP010000019; CCX53402.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5BKT0; -.
DR   Proteomes; UP000018347; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR006104; Glyco_hydro_2_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR10066; BETA-GLUCURONIDASE; 1.
DR   PANTHER; PTHR10066:SF67; BETA-GLUCURONIDASE; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   Pfam; PF02837; Glyco_hydro_2_N; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CCX53402.1}.
FT   DOMAIN          56..181
FT                   /note="Glycosyl hydrolases family 2 sugar binding"
FT                   /evidence="ECO:0000259|Pfam:PF02837"
FT   DOMAIN          213..275
FT                   /note="Glycoside hydrolase family 2 immunoglobulin-like
FT                   beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF00703"
FT   DOMAIN          313..489
FT                   /note="Glycoside hydrolase family 2 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF02836"
SQ   SEQUENCE   561 AA;  62642 MW;  EE4E4D3BBD0586AD CRC64;
     MSTMELLQPV TNVFRDSIDL RGNWFFAFDK LKDKNYETGV ARQMSVPVPA ALQDVFVSPG
     ERSYCGTMWY ERNIYISKRW LGSDVFLCFD GIGNRAVVYV NGMEAGRHEG VFVSTVINVT
     RQLRYGEENR IVVKVNNELS AYTLPAGQVA TSPKGRRINQ PNFDYDVPTG IYGNVTLYTV
     PTTRLTDIMV QTEALSQEEA VVQYMAHVQG NCLVTATLRD REGRIVATGV GGNAKLTVEN
     PHIWTVGDGY LYTLEVEVSR LGKKHDIYHQ RIGIRTVAVD GGNLMLNGAI VRLKGIELGP
     SNLTLSSNPI QAKQQLQKLL ELGGNCVFTS GRPISPDVLQ LTDEAGILVV AEMPAAGLVA
     KDWRPGEANF NKTDIKSRLL DTHKDTIDSL ITRDKNHPSV ISWSLLYNPV TMMKEDEMYY
     SDIAEAARQS DWEKRPLALT MIQSLSDIWA GTLKAYSLLI LKNWTKQWHA DVELLQSAMY
     KELVDWEAKQ PDKALAVVMG CDSATEQSGI GQMIISYAVY REASEKVQEL LTMLSSMPNV
     QGHFLQGEAA ELVETLKKNW K
//