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Entry: R5BN17_9FIRM
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ID   R5BN17_9FIRM            Unreviewed;       618 AA.
AC   R5BN17;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-SEP-2017, entry version 28.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BN814_00469 {ECO:0000313|EMBL:CCX56903.1};
OS   Veillonella sp. CAG:933.
OC   Bacteria; Firmicutes; Negativicutes; Veillonellales; Veillonellaceae;
OC   Veillonella; environmental samples.
OX   NCBI_TaxID=1262980 {ECO:0000313|EMBL:CCX56903.1, ECO:0000313|Proteomes:UP000018347};
RN   [1] {ECO:0000313|EMBL:CCX56903.1, ECO:0000313|Proteomes:UP000018347}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:933 {ECO:0000313|Proteomes:UP000018347};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCX56903.1}.
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DR   EMBL; CAWP010000215; CCX56903.1; -; Genomic_DNA.
DR   Proteomes; UP000018347; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018347};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018347}.
FT   DOMAIN      300    460       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      524    593       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     308    315       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   618 AA;  70181 MW;  C66509625857C192 CRC64;
     MSNINLNDFW NKVREDIEAT LPKEILESTI IRLLPLQLDE ISKTLTLTTM QTYIKDFIEN
     EPMIKNAFQN SVNNVWQRLT KNNSPLTIII TTPGDKEPAT LHEEVKTTVA QPSVMTPPEP
     TAFTNQPANY DDSQIASMPQ SQLGNESGYD MNEYENAPYE TAAHANETAT HAPNYSAYDQ
     LASQYGLPPA APAPSQTPLH TPNYDEPVVV DSVRKNDATK SGPYIPSTSP MESDSLFPPS
     EIPQEAASMQ SNSSQTTLYK NNESILKLNP DYTFATFIAG GSSQMAYVAA QNIAENPANR
     YNPFFIYGKS GLGKTHLMHA IGNEIHRRYP HLQIMCITSE NFLNLFVQSI RYGQTNMDIF
     RSTFRKVDVL LIDDIQFIQE KRYAGTQMEF FHTFNALTDS KKQIVLTSDV LPQDMEQMED
     RLRTRFSSGL VVTIDPPNSE TLEAITRSYV DKQRELLPNL NIPNEVIRFF GNTYYNRSVR
     DLQGALTKLI TAAELDNKLD QITVEYTRYI LRDLIPESKK SVLSVAYIQD FISDYFKIKK
     EFLVGQKRNK QYAHPRQIAM YLCRELINES FPQISQAFGK KDHTTALHAY NKISEDLAKS
     TDLKRTIDDI ISKINEDT
//
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