ID   R5BYW0_9FIRM            Unreviewed;       247 AA.
AC   R5BYW0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Thiamine pyrophosphate enzyme TPP-binding domain-containing protein {ECO:0000259|Pfam:PF02775};
GN   ORFNames=BN499_01222 {ECO:0000313|EMBL:CCX57842.1};
OS   Blautia hydrogenotrophica CAG:147.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=1263061 {ECO:0000313|EMBL:CCX57842.1, ECO:0000313|Proteomes:UP000018163};
RN   [1] {ECO:0000313|EMBL:CCX57842.1, ECO:0000313|Proteomes:UP000018163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:147 {ECO:0000313|Proteomes:UP000018163};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCX57842.1}.
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DR   EMBL; CAWR010000038; CCX57842.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5BYW0; -.
DR   Proteomes; UP000018163; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR48084; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED; 1.
DR   PANTHER; PTHR48084:SF3; SUBUNIT OF PYRUVATE:FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018163}.
FT   DOMAIN          62..206
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   247 AA;  26873 MW;  B1D26B43F6566E97 CRC64;
     MKLKKPDRIG ILPETGFCPG CGHGVVSRLV AEVADELNIN EKLVITHDVA CGYIGAAMMR
     FDSIVSAHGR PIPTASGYQK VRPDNIACAY LGDGSAYSIG VAELIHAALR NDNITVIVVN
     NTVYGMTGGQ MAPTSLPGEK TMSSVYGKDP ERYGTLNVVD LIGKQEIAYL ARGEIYDVVS
     TAKAKKMIKK AFENQMEKRG FSLVEVLSPC PTNLHMTPLK AKEYMHTEAR KYFPLGEFID
     VTKEGSK
//