ID   R5CR41_9FIRM            Unreviewed;       673 AA.
AC   R5CR41;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Xaa-Pro aminopeptidase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN785_00029 {ECO:0000313|EMBL:CCX67172.1};
OS   Firmicutes bacterium CAG:791.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1262993 {ECO:0000313|EMBL:CCX67172.1, ECO:0000313|Proteomes:UP000018038};
RN   [1] {ECO:0000313|EMBL:CCX67172.1, ECO:0000313|Proteomes:UP000018038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:791 {ECO:0000313|Proteomes:UP000018038};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCX67172.1}.
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DR   EMBL; CAWT010000251; CCX67172.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5CR41; -.
DR   STRING; 1262993.BN785_00029; -.
DR   Proteomes; UP000018038; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018038}.
FT   DOMAIN          9..137
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          394..604
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          613..673
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   673 AA;  73894 MW;  3D687C9BF8532DE5 CRC64;
     MAENRCVARL AALRGAMERN GVDTVIIPTA DYHNSEYVAD CFKAREYYSG FTGSAGILAV
     RGEEAALWAD GRYFIQAEHE LAGSGITLMK MGEPGVPTLH EWLKAEMPEN SRLAFDGRCI
     TKAEGQALAA LLDEKKVEVS AEKDLAGDTW ENRPALPKHP VFLLDAEKYA GESAESKLKR
     LRGKMAEKNV TAYVSSKLDE IMWLFNIRGN DVECNPVALS YAVVTKDKAL LYLQDEEVTG
     ELKEYAKEAG ITLRSYERFL ADLPELPLGE EAAAGAAAGT SATETVSASD GTSAAETVSA
     ADGEKQAAVR VWIDPDYTSF SVYCALLKNL DRTIREELKA EGLDLAALPA AAADKILASE
     EAKHFVETPS PVDFMKSIRN ETEIRNFRDI YVEDSAALTK FIYWLKKSMK EGAQLTEGSA
     AAYLDQLRAG ISDYVELSFP TISAYGSNAA MMHYEPGEDG GAALSPEGML LVDSGGHYLR
     GTTDVTRTMS LGPVTDEMRR SYTLTAVSQL QLMGTVFLKG CNGIALDIMA REPMWENGMD
     YKCGTGHGIG YLLNVHEGPQ TIRWREREKA DSTPLEAGMV VSDEPGVYRE GAYGIRIETI
     LLCREWGTTP DGTFLCFEPL TFAPLDRDLI DPSALTPHTR KLLNDYHRSV LEKISPYLNE
     EEKLWLSGEC AEI
//