ID   R5CVW6_9BACT            Unreviewed;       718 AA.
AC   R5CVW6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Penicillin-binding protein transpeptidase domain protein {ECO:0000313|EMBL:CCX68847.1};
GN   ORFNames=BN567_02619 {ECO:0000313|EMBL:CCX68847.1};
OS   Prevotella sp. CAG:255.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1262923 {ECO:0000313|EMBL:CCX68847.1, ECO:0000313|Proteomes:UP000017913};
RN   [1] {ECO:0000313|EMBL:CCX68847.1, ECO:0000313|Proteomes:UP000017913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:255 {ECO:0000313|Proteomes:UP000017913};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCX68847.1}.
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DR   EMBL; CAWV010000086; CCX68847.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5CVW6; -.
DR   Proteomes; UP000017913; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005543; PASTA_dom.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03793; PASTA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SMART; SM00740; PASTA; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 1.
DR   PROSITE; PS51178; PASTA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          657..718
FT                   /note="PASTA"
FT                   /evidence="ECO:0000259|PROSITE:PS51178"
SQ   SEQUENCE   718 AA;  79741 MW;  A66B6019DC5827C7 CRC64;
     MSNKFDRKKI IPRYKIIAYV MVVIGIIIIG KAMCIATVER DYWLKVASRL KKDSVDMKPV
     RGNILSCDGR LMASSLPEYR LFMDFKAGGE EKDSLWQVKL DSICMGLHEI FPEKSAAKFK
     EDLEKGRKKK SQHWPIWKYR VSYDVYSEVK KLPVFNLSKY KSGFHVETYN ARQRPFGSLA
     QRTVGDMYGD KDSARCGLEL YYDTILRGKM GKISRRKVMN KYLSITTREP VNGADIVTTI
     DVGMQDLAER ALIDELKEIN GNVGVAIVME VKTGDVKAIV NMTKCADGEY REIKNSAVSD
     LLEPGSVFKT ASIMVALDDG VVDTTYKVDT GNGIWDMYGA KMRDHNWHRG GYQMLTLPQT
     LEYSSNIGVS RIIDKFYHDK PEKFVEGIDR LGLRTDLHLP IVGYAAPKIR MPKKNGKGQY
     VNWSKTALPW MSIGYETQVP PISTLTFYNA IANNGTMMRP RFVKQIVKDG EVIAEFPPEV
     IKARICKEKT LREIQTILEH VVSQGLGKRA GSTSFKVAGK TGTAQISKGA GGYKSGKVNY
     LLSFAGYFPA DDPRYSCIVC IQKSGLPASG GGMSGLVFHN IAEGIMAQSL KLSVEDARDS
     LSILMPDVKS GNILAADYVL SHLGISTNKN WSGSYANGNP IWGSAKREAS SVMLTRGPHY
     ETKIVPDVIG MGARDAVYIL ESRGVKVRLS GRGKVTQQSL PAGHIIKKGE VCSLKLEI
//