ID   R5EAM9_9CLOT            Unreviewed;       735 AA.
AC   R5EAM9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Phosphoglycerol transferase and related proteins alkaline phosphatase superfamily {ECO:0000313|EMBL:CCX89493.1};
GN   ORFNames=BN724_00629 {ECO:0000313|EMBL:CCX89493.1};
OS   Clostridium sp. CAG:590.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262825 {ECO:0000313|EMBL:CCX89493.1, ECO:0000313|Proteomes:UP000017939};
RN   [1] {ECO:0000313|EMBL:CCX89493.1, ECO:0000313|Proteomes:UP000017939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:590 {ECO:0000313|Proteomes:UP000017939};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004936}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCX89493.1}.
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DR   EMBL; CAXF010000244; CCX89493.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5EAM9; -.
DR   STRING; 1262825.BN724_00629; -.
DR   Proteomes; UP000017939; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd16015; LTA_synthase; 1.
DR   Gene3D; 3.30.1120.170; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017939};
KW   Transferase {ECO:0000313|EMBL:CCX89493.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        41..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        70..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        123..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          339..653
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          254..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..287
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  83714 MW;  5B459C572A802B35 CRC64;
     MLEKGKSGKI AFQARWLIPL FMMVLEVVFH VAAFGKMDTN ICNGILFTLP FSFFVLLVSS
     TKHRSWNRVV RGVLLLLMII YGITQMIYQQ VFGNFLSLKS VSKGAGQAMD FTSTILQAGK
     EKAAAILCMI LLWIVYVVAD AYFDKKSDGE DIQVGRRERL LYAAGVLLLP VVGTVILLIE
     GTGFHSAFDT KVHFHRTEQS MYKLGMTETL TKDMAENICD GLGITERQWN RGYLWVEEWL
     GGSDKEDLAQ ERKGDMGISD PEDVKGNLAG NVEPKKEDGS VQEDGISEKK ETRYHEWNID
     FAELAKESTD EELKDMHSYF SRISPTAENS YTGMFEGYNL VYITAESFSD VIIDKERTPV
     LYQMWKEGVQ FENFYTPSWY LSTIDGEYVN CLGQIPVDGD WSLEHASEGE LPMALGNQLQ
     QKGYVCNAYH DHDSYYYDRT KTHPKLGYTF KAVGAGLTFE SMYPESDLEL MEITADEYVN
     KAPFHTYYMT MSGHLPYTYG YNSMAVKNRE VTEGMDLTEN AACYLEANQE LEYALEYLVD
     QLKQKGQLEH TLFVVAPDHY PYGLKKGAYD ELRKATGHVI DENDVLHMER EGNADAGDSD
     IDVITVEQDD FELYRNTCLI WSAAMENMDE FPMTVEKCCS NLDLLPTISN LMGLDYDSRL
     LAGRDMLSDD MGLVMFKDQS FLTDRVRYNA TTGETVWMGG TEDESYLQQC MQMVENRFRY
     SALVLQKDYY SVVKP
//