ID R5HZ60_9BACT Unreviewed; 670 AA.
AC R5HZ60;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Beta-N-acetylhexosaminidase {ECO:0000313|EMBL:CCY34995.1};
GN ORFNames=BN796_01691 {ECO:0000313|EMBL:CCY34995.1};
OS Alistipes sp. CAG:831.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC Alistipes.
OX NCBI_TaxID=1262698 {ECO:0000313|EMBL:CCY34995.1, ECO:0000313|Proteomes:UP000018094};
RN [1] {ECO:0000313|EMBL:CCY34995.1, ECO:0000313|Proteomes:UP000018094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:831 {ECO:0000313|Proteomes:UP000018094};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY34995.1}.
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DR EMBL; CAYB010000048; CCY34995.1; -; Genomic_DNA.
DR AlphaFoldDB; R5HZ60; -.
DR STRING; 1262698.BN796_01691; -.
DR Proteomes; UP000018094; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06564; GH20_DspB_LnbB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR43678:SF1; BETA-N-ACETYLHEXOSAMINIDASE; 1.
DR PANTHER; PTHR43678; PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000018094};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..670
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004392881"
FT DOMAIN 31..168
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 171..490
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 332
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 670 AA; 75652 MW; FA1C391E1D65E6D8 CRC64;
MKRHLYFLIS TFAAALYSIS VFAATEEKTG PFVIPELKTW EAGKGAMTVS GTMRIAVPSG
DEELLRIAGM LAEDWKTMFG YLPGIVTEKG TEGDIVLEIK NDKRLDRLSG GSAESYSISI
TDRVRLSAAT ARGVFWGTQT ILQMADRSIP GGARDIAVSL PCGKVLDWPD YGLRGFMMDC
GRKYIPMSYL RKLTRIMAYY KMNTLQVHLN DNGFKQYFGG DWDRTYAAFR LECDTYPGLT
ARDGHYTKEE FIDFQEEASG MYVEIIPEID VPAHSLALTR YKPEIGSQEY GMDHLDLFNP
ETYTFVDALF KEYLEGGEPV FRGPRVHIGT DEYSNKDQDV VEKFRYFTDH YIRLVESYGK
QAVVWGALTH ADGETPVKSE NVIMNAWYNG YADPRQMVED GYKLISIPDG LVYIVPAAGY
YYDYLDEQNL YENWTPAHVG DAVFAERDTA ILGGMFAVWN DHAGNGISVK DIHDRLFPAL
QTLSVKMWTG TETALPYADF DSTRRYVREA PGINFSGRIG TEPGCVLEMA EVTPGSSLPY
PEIGYDYTVS FTIEGKAEKP GTELFRSEDA VFYLSDPVSG MMGFARDGYL NTFRYSIQDG
DRLEVTVKGD NRSTTLIVNG RVIDRLEIEK RWHNEGKSVM YYVPTLVFPL QQAGDYRSRI
TDLKVYNHQL
//
