ID   R5J5G1_9CLOT            Unreviewed;       707 AA.
AC   R5J5G1;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Penicillin-binding transpeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN757_00630 {ECO:0000313|EMBL:CCY44276.1};
OS   Clostridium sp. CAG:7.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262832 {ECO:0000313|EMBL:CCY44276.1, ECO:0000313|Proteomes:UP000018268};
RN   [1] {ECO:0000313|EMBL:CCY44276.1, ECO:0000313|Proteomes:UP000018268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:7 {ECO:0000313|Proteomes:UP000018268};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCY44276.1}.
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DR   EMBL; CAYE010000176; CCY44276.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5J5G1; -.
DR   STRING; 1262832.BN757_00630; -.
DR   Proteomes; UP000018268; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR007887; MecA_N.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627:SF25; PENICILLIN-BINDING PROTEIN 3; 1.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   Pfam; PF05223; MecA_N; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018268}.
FT   DOMAIN          49..160
FT                   /note="NTF2-like N-terminal transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF05223"
FT   DOMAIN          168..351
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          385..684
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   707 AA;  78650 MW;  4794E5AAC3971367 CRC64;
     MKKGKSRNKR KKTRSRLLWI AIAVIGIAAV ISAVCVAGML ATKENAWKTP EELLVEYMDH
     IPKQEYEEMY AMLHIEASGN VSQEDFVTRN SAIYEGIEVQ NIAVQIIAYD EEQMTVTYQT
     SFDTVAGTIS FENKALFLKD EEGYQLVWDD SLIFPNLAST DKVRVSTTQA ERGEILDRNG
     RVLAGKGTAS SVGIVPGKLE NREEAIAQIA ELVEITPEAI EKKLSAKWVK DDSFVPIKTI
     PRVEEIELMS ISPDEEVLKE KERHEKLLEI PGVMISDVEV REYPLGEAAA HLVGYVQSVT
     AEDLEEHAGE GYTANSVIGR SGMESLFESE LKGQNGCRIY IENSEGKEKE ELACILVQHG
     QDIQLTIDTD LQVSLHEQFK EDKSCSVAMN PYIGEVLALV STPAYDNNDF IMGLSSEQWT
     VLNEDENKPM YNRFRQVWCP GSTFKPIIAA IGLQSGAIDP MEDYGNVGLS WQKDASWGSY
     HVTTLHAYEP VILENALIYS DNIYFAKAAL KIGSDELENS LIRLGFNEEL PFEIKMAESQ
     YSNTEGIETE IQLADSGYGQ GQILVNPLHM ACIYSAFCNE GNVIKPYLVY QNEAEAEYWI
     PGAFSNETAS RVLEGTKKVV NNPNGTGYAA HRDDIILAGK TGTAEIKESK EDTSGTELGW
     FAIYTAEKDI EYPILIISMV EDVKGRGGSG YVVKKDSLVL EEWFSSH
//