ID R5JKR1_9FIRM Unreviewed; 763 AA.
AC R5JKR1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN738_00926 {ECO:0000313|EMBL:CCY49387.1};
OS Peptostreptococcus anaerobius CAG:621.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Peptostreptococcus.
OX NCBI_TaxID=1263100 {ECO:0000313|EMBL:CCY49387.1, ECO:0000313|Proteomes:UP000018261};
RN [1] {ECO:0000313|EMBL:CCY49387.1, ECO:0000313|Proteomes:UP000018261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:621 {ECO:0000313|Proteomes:UP000018261};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY49387.1}.
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DR EMBL; CAYH010000090; CCY49387.1; -; Genomic_DNA.
DR AlphaFoldDB; R5JKR1; -.
DR Proteomes; UP000018261; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF3; ATP-DEPENDENT HELICASE_DEOXYRIBONUCLEASE SUBUNIT B; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000018261}.
FT DOMAIN 3..327
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 328..635
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 763 AA; 88766 MW; 4F0F77044EAAE4E3 CRC64;
MSINYRKDQK KIMKYKSGSM GIQAVPGAGK TFIITNLVAQ LIEDMENENR DGKILVLTYM
NSAVNNFKSR IRGILSDKDL PKSRFEVMTI HSLAMKIIKE NTDIAFVSEE TEIIDDYKKS
LLINSAIEEY ESRDNNSNKI LSFMEKGFRN NEDKVDRWYK EFTFMVLNSI KLLKYSGIDD
IDLKNIVNEP DYKGIMTIIS PIFNLYQEKL RSNAYIDYDD ILVMAYKILE SDSEVAAYYQ
ERYAYVFEDE CQDSNEIQGK IIEIISRNVS RSISENDMVS AKMNLVRVGD VNQSITTTFA
GSNPKFFVDF CKKADKSYTM NMAGRSSKDI INTANKLVEI VKSDMTKDYY GGLEEIYIEE
VEKDKGYKEN PVTRSYSINS KSLDDFNQEM DYVVSTIKYT REKFPNYSIG VLYFSNFDVN
DLAKKLDSED IPYEKIGNDS QENMKIIYKI KLVVDFIIDP SDYDIFKQML FEAYIDRADT
YELSDIEHER LEKLFDKIDT ERYFYDDLYF DDLATRAKQL LENLIEKPFV KKLAEDRARI
RSVLEYSKVD IYGLIKLIGD SLNISSQEKK LIDYLAFYLS KLKTYESADL NRISIAMAPR
NTRIFETLVA SIYDIGEHEV EAGSISISTM HKSKGMEWDL VIVCGVSSND FPSSVNDYFR
IDRKYLREGF KYPEAFVNKE IDDIVNKSCK KIGYYEKELK TEIIGERTRL LYVAITRAKR
GLVILNSRSR FNESMNYYFK KKNSYFFDIL SKYISDNRIK GGK
//
