ID R5KDS7_9BACT Unreviewed; 567 AA.
AC R5KDS7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Glycosyl hydrolase family 43 {ECO:0000313|EMBL:CCY64890.1};
GN ORFNames=BN467_00210 {ECO:0000313|EMBL:CCY64890.1};
OS Prevotella sp. CAG:1124.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262920 {ECO:0000313|EMBL:CCY64890.1, ECO:0000313|Proteomes:UP000017956};
RN [1] {ECO:0000313|EMBL:CCY64890.1, ECO:0000313|Proteomes:UP000017956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:1124 {ECO:0000313|Proteomes:UP000017956};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY64890.1}.
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DR EMBL; CAYO010000124; CCY64890.1; -; Genomic_DNA.
DR AlphaFoldDB; R5KDS7; -.
DR Proteomes; UP000017956; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd18617; GH43_XynB-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF12; BETA-XYLOSIDASE-RELATED; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000017956};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..567
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004395746"
FT DOMAIN 386..566
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT ACT_SITE 71
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 244
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 179
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 567 AA; 62954 MW; C22AD9082B73DF7C CRC64;
MKRKSIIRFT TLAMLAYAMP NFASAVADGQ DEGFAMFDNF VYSGNDDFYN SNPLPGPSSF
YNPILPGWNS DPSICRAGND YFMVTSTFSY FPGVPLFHSK DLLNWKQVGY VLDRPSQLPL
DGQKTSEGIF APAISYNPNN KTFYMITTNI RLGNFFVKTK DPFGEWSDPI RLPDVGGIDP
SFFFDDNGKA YIVNNDAPEG PAEYDGHRAI KVREFDVATD KTVGPTKVLV NKGVHPEDKP
IWIEGPHMYK INGKYYLMDA EGGTSDMHSE VIFRSDSPFG PFVPAKQNPI LTQRHLPADR
PNPVTCAGHA DLVQTPEGDW YAVFLACRPY DGKSENLGRE TFLMPVRWNA DGFPYITEGN
ETVPLVSEVK GATRGNDVTF GNFTYKDDFS SAELDLGWFS LRAPASTFCS LSKNKGYLTM
PCIDVKASEM KTPALVTRRI SHHKFECSTR LTFSPAQAGD KAGLMLYKDE NHQYLLCVVK
TNDGRQVEVL KVSDGGAEEV MAFSPINNDN NDISLKVTSD GPTFSFHYSK NGNDWETLKT
GVDAYYLTTR NAGGFTGTTI GLYTSSK
//
