ID   R5KNR7_9FIRM            Unreviewed;       495 AA.
AC   R5KNR7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Pyridine nucleotide-disulfide oxidoreductase {ECO:0000313|EMBL:CCY68388.1};
GN   ORFNames=BN508_00102 {ECO:0000313|EMBL:CCY68388.1};
OS   Eubacterium sp. CAG:161.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262881 {ECO:0000313|EMBL:CCY68388.1, ECO:0000313|Proteomes:UP000018318};
RN   [1] {ECO:0000313|EMBL:CCY68388.1, ECO:0000313|Proteomes:UP000018318}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:161 {ECO:0000313|Proteomes:UP000018318};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCY68388.1}.
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DR   EMBL; CAYQ010000013; CCY68388.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5KNR7; -.
DR   STRING; 1262881.BN508_00102; -.
DR   Proteomes; UP000018318; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR006005; Glut_synth_ssu1.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   NCBIfam; TIGR01317; GOGAT_sm_gam; 1.
DR   PANTHER; PTHR43100; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   PANTHER; PTHR43100:SF1; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018318}.
FT   DOMAIN          23..139
FT                   /note="Dihydroprymidine dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF14691"
FT   DOMAIN          153..478
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   495 AA;  54491 MW;  4269CB5A9089ADD4 CRC64;
     MGKPTGFLEY EREEAKATSP KERIKNFNEF HEPLSVDKQK CQAARCMDCG VPFCQNGKVI
     AGMVSGCPLN NLIPEWNDLL YNGNMEQAYN RLHKTNNFPE FTSRVCPALC EKACTCGLNG
     DAVSVRANEH LIIENAYEKG YASAKAPHVR TGKKVAVIGS GPSGLAVADQ LNKRGHSVTV
     YERDDRIGGL LMYGIPNMKL EKHIIDRKVN IMKEEGVTFV TNTNVGKDVK AADILKKYDK
     VVLACGSRHA RDINAKGRDA KGIYFAVDFL TSTTKSLLDN GKLVDGTYVS AKDKDVVIIG
     GGDTGNDCVG TSIRHGAKSV LQLEMMPKAP DERAANNPWP EWPRICKTDY GQEEAIAVFG
     HDPRVYQTTV KEFVKDKEGN LCKLILVKLE AKKDEKTGRM NMVEIPGSEY EVDCQLVLIA
     AGFLGSEDYV TKAFKVDTTP RTNIATMPGK YATSVENVFT AGDVHRGQSL VVWAIREGRD
     CAKEVDESLM GYTNL
//