ID R5NBF5_9FIRM Unreviewed; 716 AA.
AC R5NBF5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN ORFNames=BN804_00966 {ECO:0000313|EMBL:CCY94532.1};
OS Firmicutes bacterium CAG:884.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1262990 {ECO:0000313|EMBL:CCY94532.1, ECO:0000313|Proteomes:UP000018073};
RN [1] {ECO:0000313|EMBL:CCY94532.1, ECO:0000313|Proteomes:UP000018073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:884 {ECO:0000313|Proteomes:UP000018073};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate;
CC Xref=Rhea:RHEA:22088, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:142410, ChEBI:CHEBI:456215; EC=2.7.6.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001157};
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY94532.1}.
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DR EMBL; CAZD010000050; CCY94532.1; -; Genomic_DNA.
DR AlphaFoldDB; R5NBF5; -.
DR STRING; 1262990.BN804_00966; -.
DR UniPathway; UPA00908; UER00884.
DR Proteomes; UP000018073; Unassembled WGS sequence.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018073}.
FT DOMAIN 49..148
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 392..453
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 716 AA; 82812 MW; EF657F2A66BB749B CRC64;
MERTYNTYEE LKELLKTYIK DEDLELIDEC YDFAFKCHQG QRRITGEDYI YHPISVAYIL
ASINADKETI GAALLHDVLE DCNITREEME EKFGKEITKI VYGVTKINKL NFNDESEVLI
ANHRKIIVGL AEDVRVIILK LADRLNNLRT LWALPEEKQK KKAKETLEIL TPIADRLGMN
KMKSEMEDLA LRYLKPDTYF DILEKLNQTK AEREALVLEM QDKITTLLTE NDIKHEIKGR
AKSIYSIYKK LEKGRRWSDI YDIYALRVFV DTEAECYQVL GIIHSKFRPI PKRFKDYIAM
PKTNMYQSLH TTVFGVGGNA FEVQIRTYAM DKVAESGIAS HWSYKERGSV KANLQNAMEQ
KLQFFKTIME LEQENLSKEE FVNTVTNEVF NDTIYVFTPA GDVIELPNGS TPIDFAYKVH
SNIGNHMVSA IVNGAIRPLN EELKDNDIIK IQTSPSAKPS EEWLKVAKTT QAKQKIKDYF
KRIAKDGYYK KGQELIAKEL RRKKITNQEF FKDENIEKIL NQLKLNNLDE LYINVGDNKI
GVNQIINILK EENLSKEELI LKKASDQKVK YSYNDLYVDG VENMKINVAH CCNPVPGDKI
IGYVTKGNGV TVHRLICPNI EDEEERTIEV KWGNEIKSKY ESMLVLHANE NKSLLMDIIT
KAQNRDISVT YMNNIFANDL YYIEIKILVK DLDTLNTFIN DVSNLSEVID VERVIQ
//