ID   R5PFI6_9BACT            Unreviewed;       312 AA.
AC   R5PFI6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alani ne ligase {ECO:0000313|EMBL:CCZ15370.1};
GN   ORFNames=BN679_02176 {ECO:0000313|EMBL:CCZ15370.1};
OS   Prevotella sp. CAG:487.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1262928 {ECO:0000313|EMBL:CCZ15370.1, ECO:0000313|Proteomes:UP000018275};
RN   [1] {ECO:0000313|EMBL:CCZ15370.1, ECO:0000313|Proteomes:UP000018275}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:487 {ECO:0000313|Proteomes:UP000018275};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ15370.1}.
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DR   EMBL; CAZM010000341; CCZ15370.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5PFI6; -.
DR   Proteomes; UP000018275; Unassembled WGS sequence.
DR   GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR   Gene3D; 3.40.1390.10; MurE/MurF, N-terminal domain; 1.
DR   InterPro; IPR036565; Mur-like_cat_sf.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR000713; Mur_ligase_N.
DR   InterPro; IPR035911; MurE/MurF_N.
DR   PANTHER; PTHR43024; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR   PANTHER; PTHR43024:SF1; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR   Pfam; PF01225; Mur_ligase; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR   SUPFAM; SSF63418; MurE/MurF N-terminal domain; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:CCZ15370.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018275}.
FT   DOMAIN          15..75
FT                   /note="Mur ligase N-terminal catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01225"
FT   DOMAIN          95..281
FT                   /note="Mur ligase central"
FT                   /evidence="ECO:0000259|Pfam:PF08245"
SQ   SEQUENCE   312 AA;  34495 MW;  6EF6A3A1194A104F CRC64;
     MEIEHLYRLF SEHQTVTTDS RDCPEGSIFF ALKGESFDGN RFAETALQKG CSYAVIDEPE
     YARDERYIVT DNALATLKQL ARHHRRQFDI PVIGITGTNG KTTTKELVAA VLSKKYKVLY
     TEGNFNNDIG VPKTLLRLRK EHEIAVIEMG ASHPGDIKTL VETVEPDYGL ITNVGKAHLQ
     GFGSFEGVVR TKGELYDFLR RRNGSKVFID AANRHLAGIS GGLDLIKYAC EPMDGLYVEG
     EVTSCAPLLC FRWRGGGGGW HEVETHLIGT YNLCNMLAAA SIGLYFGVGD DAVSDALAGY
     IPHQPPWTIY LT
//