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Database: UniProt
Entry: R5PV36_9FIRM
LinkDB: R5PV36_9FIRM
Original site: R5PV36_9FIRM 
ID   R5PV36_9FIRM            Unreviewed;       339 AA.
AC   R5PV36;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   15-MAR-2017, entry version 21.
DE   RecName: Full=Lipoate--protein ligase {ECO:0000256|SAAS:SAAS00603724};
DE            EC=6.3.1.20 {ECO:0000256|SAAS:SAAS00603724};
GN   ORFNames=BN766_01051 {ECO:0000313|EMBL:CCZ20038.1};
OS   Ruminococcus sp. CAG:724.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminococcus; environmental samples.
OX   NCBI_TaxID=1262966 {ECO:0000313|EMBL:CCZ20038.1, ECO:0000313|Proteomes:UP000018243};
RN   [1] {ECO:0000313|EMBL:CCZ20038.1, ECO:0000313|Proteomes:UP000018243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:724 {ECO:0000313|Proteomes:UP000018243};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-lipoate + a [lipoyl-carrier
CC       protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine
CC       + AMP + diphosphate. {ECO:0000256|SAAS:SAAS00603726}.
CC   -!- PATHWAY: Protein modification; protein lipoylation via exogenous
CC       pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
CC       {ECO:0000256|SAAS:SAAS00701662}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCZ20038.1}.
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DR   EMBL; CAZP010000054; CCZ20038.1; -; Genomic_DNA.
DR   UniPathway; UPA00537; UER00595.
DR   Proteomes; UP000018243; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009249; P:protein lipoylation; IEA:InterPro.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR019491; Lipoate_protein_ligase_C.
DR   InterPro; IPR004562; LipoylTrfase_LipoateP_Ligase.
DR   PANTHER; PTHR12561; PTHR12561; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF10437; Lip_prot_lig_C; 1.
DR   TIGRFAMs; TIGR00545; lipoyltrans; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00428641};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018243};
KW   Ligase {ECO:0000256|SAAS:SAAS00603725, ECO:0000313|EMBL:CCZ20038.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00026749};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018243}.
FT   DOMAIN       24    211       BPL/LPL catalytic. {ECO:0000259|PROSITE:
FT                                PS51733}.
SQ   SEQUENCE   339 AA;  37525 MW;  5365D8D82823894B CRC64;
     MILVKNTNTE PYKNMAFEEY LLRTCDEPAV MLWRNEPAVI IGKNQNAREQ VNFDFTLAHG
     VKTVRRLTGG GAVFHDLGNV NYTFITPATA DDRINFAYFC RPVIEALSGL GIKAALSGRN
     DLTVSDGRKF SGTAACAFEY GGKTKLMHHG TLLFSADMSY LTDALKVDPD KIQSKGIKSV
     KSRVTNLCEH ISTEFADMTA EGFKEYLENY FIGNGAKLVI PDDAALFEIE KLAEEKYASE
     AWLFGAKTES AAQVKAKRFD FGKVACETEY LYEVGKSAKI KRVKFSGDFF GTKPIEELEK
     MLCLTEAKIC DIIDVLEKAP LSAYICGAAP EEICSLILL
//
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