ID R5QFD9_9FIRM Unreviewed; 831 AA.
AC R5QFD9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Stage 0 sporulation protein A homolog {ECO:0000256|ARBA:ARBA00018672};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BN766_00844 {ECO:0000313|EMBL:CCZ19827.1};
OS Candidatus Apopatosoma intestinale.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Apopatosoma.
OX NCBI_TaxID=1262966 {ECO:0000313|EMBL:CCZ19827.1, ECO:0000313|Proteomes:UP000018243};
RN [1] {ECO:0000313|EMBL:CCZ19827.1, ECO:0000313|Proteomes:UP000018243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:724 {ECO:0000313|Proteomes:UP000018243};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play the central regulatory role in sporulation. It may
CC be an element of the effector pathway responsible for the activation of
CC sporulation genes in response to nutritional stress. Spo0A may act in
CC concert with spo0H (a sigma factor) to control the expression of some
CC genes that are critical to the sporulation process.
CC {ECO:0000256|ARBA:ARBA00024867}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ19827.1}.
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DR EMBL; CAZP010000034; CCZ19827.1; -; Genomic_DNA.
DR AlphaFoldDB; R5QFD9; -.
DR STRING; 1262966.BN766_00844; -.
DR Proteomes; UP000018243; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CCZ19827.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000018243};
KW Transferase {ECO:0000313|EMBL:CCZ19827.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 453..681
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 702..823
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 754
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 831 AA; 93472 MW; 665338718E3E1557 CRC64;
MMLGTLFFSI EYSRRKAQKT MDRNISDLKK QINDYNEFLA ADEVKSLIRL TEKAESLSEA
LAMLDDGARQ EYIERIYDSQ RLSCILVLDE NLNPDNFMRT VKCNGTADEC YESWIAELQS
PAIKAISDHP KKVYSARIRH GGDNYDIAAV ARTDAKGIIF CASRQADKKL ELHYSPVRNL
LARNETRLDG TLCIAEDGRI IATNLDGAYA GADEIPELTA LKERKAGNEL TMIVSGGDVF
YGGIVKCRNY DIYAFYPAGA IYSPCRAIML FAFSVYVMIV FIIGFFHSKA RAERAREINR
QYETIQAISH VYSLTALIDL KANHYELLKY PPDLSNVAKD GTLDTRFCKE IIGYVDERFR
EGYRDFLNTE TMTERLAEAE YAEYEYQNRN GDWINDKLIV REKDKEGRVD SVILARSSIN
EQKKAELEYQ AKLETAVRNE QTANQSKTDF LRRMSHDIRT PINVILGMLE IANRNPTDTE
LLASCRSKTQ TAAEYLLELV NDILTLNRAG VRNSDDIPMT EEFRLQEEVR KLYLIAAETA
KRYDGVILEP FRISGEDKPL VGEPLYLRQI MINIIANAIR YSKNGGTVRC SVSQNPAQNR
DGYAEVRFIC EDNGIGMSKE FQKRMFEPFA QESAVSVSHF GGVGLGLSIV QKLVDRLNGT
IEVDSEQGRG TRFEVKIFYP YANTHDEAET HTYANASLAG LTVLIVEDNE LNMEIAGYMA
AEAGASVVRA FDGRQAVEKF AASAVGEINV ILTDVIMPEM DGLEETRRIR ALDRPDAKTV
PIIAMTANLF EDDIREYTDA GMTGVLPKPL NMSQMVETVA KQTAKGGKNN G
//
