ID R5QUP9_9FIRM Unreviewed; 633 AA.
AC R5QUP9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BN747_00141 {ECO:0000313|EMBL:CCZ32368.1};
OS Firmicutes bacterium CAG:646.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1262995 {ECO:0000313|EMBL:CCZ32368.1, ECO:0000313|Proteomes:UP000018386};
RN [1] {ECO:0000313|EMBL:CCZ32368.1, ECO:0000313|Proteomes:UP000018386}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:646 {ECO:0000313|Proteomes:UP000018386};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ32368.1}.
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DR EMBL; CAZW010000002; CCZ32368.1; -; Genomic_DNA.
DR AlphaFoldDB; R5QUP9; -.
DR STRING; 1262995.BN747_00141; -.
DR Proteomes; UP000018386; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CCZ32368.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018386};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 128..382
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 633 AA; 73108 MW; BB43608B05C0A30B CRC64;
MQPIIKDIIL SISDDVVSNL TQSFEKTYYG KMNYSSKNTI LDSDNKLLKE TIGFEIAFIH
VITYFLAYSM SCSHEYMHIL NILDTDKLFS WFKIKDNSMF LQLNDCNIPT EKEIYELINE
HDKFIDKDVK KKLGQFYTPT GIAKKMVFEV RNELKDLSER DLVVDPACGT GVFVVETVKQ
MSAFLSFDEL IKFVENNMFA YDVNPFSVIA TKISVLNTLL EIAPDSVHKN NLLLGIPALN
NIKWKNTIVD KEEKEFSIIL GNPPYFKLDS KALKDIDGYD AIIYGQPNIY SLFMHWGISH
LRTNGTMSFI VPQSIRSGLY FKNLREEMKE LRIKSILHID SRQNIFDRAE QAVFIICLQN
KPVCNTKTRI QFINGNQNVL SEFSISRSKL MMGKDNNYMF IINKKSEMYD VLEKVYKNGT
TLSVNDSLVK FSNGLFVWNQ HKESLADSSD KAIPIVYGGD VQPVNFQFIT SWANDERKAF
ARITDKTRPY VLSGKRLLVQ RTTNFEKDIR LKACLISDDF LENYDSYFLE NHVNFLCCNS
GKEEILTDEI MYYYLGLLNS KLINYVFISK SGNTQVSANE LNLLPFSKNN VKDISAFVSK
YLSELREHQE ELDRLVCEAY DLSVNEINMI LDY
//
