ID   R5QZ47_9FIRM            Unreviewed;       436 AA.
AC   R5QZ47;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=M18 family aminopeptidase {ECO:0000256|RuleBase:RU004387};
DE            EC=3.4.11.- {ECO:0000256|RuleBase:RU004387};
GN   ORFNames=BN526_02224 {ECO:0000313|EMBL:CCZ27571.1};
OS   Firmicutes bacterium CAG:194.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263008 {ECO:0000313|EMBL:CCZ27571.1, ECO:0000313|Proteomes:UP000018384};
RN   [1] {ECO:0000313|EMBL:CCZ27571.1, ECO:0000313|Proteomes:UP000018384}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:194 {ECO:0000313|Proteomes:UP000018384};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU004387};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|ARBA:ARBA00008290, ECO:0000256|RuleBase:RU004386}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ27571.1}.
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DR   EMBL; CAZT010000009; CCZ27571.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5QZ47; -.
DR   Proteomes; UP000018384; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.250.10; Aminopeptidase i, Domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; ASPARTYL AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR28570:SF3; ASPARTYL AMINOPEPTIDASE; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000256|RuleBase:RU004386};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018384};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   436 AA;  47355 MW;  E1174B17AB791DA5 CRC64;
     MQTNTRSAID ALSVLSQSAH SPFHCCKYCE DTLKKAGFLA LPKNEPISLT PGGKYYIDLY
     DATCIAFTVG KKVSAGKKLP KLRMITAHTD WPSFLIKPQP ELTQGSYGKL NIEPYGGAVY
     TSWLDRPLGI AGKVCTKGKD AFHPVTHLID SKKPVAIIPG LAIHMNPEIN KGIQLNPQLQ
     LLPLVARLGA DEKSDYFLHY LELLTGCKAE DILDYELFLY NADPSAEVGL NGEFFSCPRI
     DNYSSVQAAL SALLHADTKE DHICISAFYH NEEIGSATKQ GAGSVMTMDL LKRIFAALGF
     SEEMLSCTIA EGLCLSLDVA HGLHPNYPDK NDPTCQICLG DGVALKLSAR QSYATDSSYV
     SVIEGICRQH NIPYKKFVNR SDQRGGSTLG SITSAKLAIP CVDAGVPILS MHSARELMAC
     TDQEALCALA AQMFRG
//