ID R5SQP7_9CLOT Unreviewed; 870 AA.
AC R5SQP7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Small GTP-binding protein domain {ECO:0000313|EMBL:CCZ53164.1};
GN ORFNames=BN771_01569 {ECO:0000313|EMBL:CCZ53164.1};
OS Clostridium sp. CAG:75.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262836 {ECO:0000313|EMBL:CCZ53164.1, ECO:0000313|Proteomes:UP000018032};
RN [1] {ECO:0000313|EMBL:CCZ53164.1, ECO:0000313|Proteomes:UP000018032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:75 {ECO:0000313|Proteomes:UP000018032};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ53164.1}.
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DR EMBL; CBAE010000263; CCZ53164.1; -; Genomic_DNA.
DR AlphaFoldDB; R5SQP7; -.
DR Proteomes; UP000018032; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd10912; PIN_YacP-like; 1.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR010298; YacP-like.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF05991; NYN_YacP; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000018032}.
FT DOMAIN 1..227
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 870 AA; 98783 MW; 1C50BD1AAC0E69AF CRC64;
MKHITIGILA HVDAGKTTLS EGLLYTAGSI RQLGRVDDQN AFLDNNHMER DRGITIFSKP
ARFALQDGTV TLLDTPGHVD FSAEMERALQ VLDYAVLVVS AADGVQSHTE TLWQLFAYYD
IPVFLFINKM DMPDTDRGRI MQELQEKLSD ACVDFMAEPE SVMEAAAMCE EDLLERFLQD
GTLEDADVIR LIRQRKLFPC YFGSALKMQG VETFLKGLWQ YTEPGQYGDE FGARVYKISR
DEQGNRLTHL KVTGGRLQAR QLLQGKKQLQ SDDGDEEQIW SEKINQIRFY SGEKYTTAKE
AKAGEICAVT GLSHTYPGEG LGFMEHDEVP ILEPVLTYRI FLEPDWDVRR ALPLLKQLEE
EEPELHIIWD ETLKELHAQV MGEVQIEVIR QQLFDRYRMH VTFGEGNIVY KETIAAPVIG
MGHFEPLRHY AEVHLLLEPG EPESGLVFDT NCSEDMLSKN WQRLILTHLQ EKKHRGVLTG
SEITDMRISV IAGKAHVKHT EGGDFRQATY RAVRQGLRQA ETILLEPYYS FRLELPTEQL
GRAMTDMERM SAKLNAPDSS GEYAVLAGEA PVATIRSYQK DLSAYTGGKG KMSCQLCGYR
PCHNTEEVVA QIGYDPDLDY AATADSVFTA HGSGYIVPWN EVADHVHVDN GYSLEGKQSP
EDDYAEPMTA AMRRRRRYDT EYSMGEEEIR SILGQAGGAN RNQKKNWIRQ RKRVVSSTDS
RGPVAYKRSA EKYLLVDGYN IVFAWDELNE LAKDNIDAAR DRLMDILCNY QAYMGMTLIL
VFDAYKVKGG IGQMLDYHNI HVVYTKEAET ADQYIEKLAH NMGREHDVTV ATSDGLEQLI
IRGQGCKLWS AREFYAEVKR VEEAIRRQVE
//
