ID   R5U9N6_9BACE            Unreviewed;       653 AA.
AC   R5U9N6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Alpha-glucosidase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN535_01107 {ECO:0000313|EMBL:CCZ74888.1};
OS   Bacteroides caccae CAG:21.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1263037 {ECO:0000313|EMBL:CCZ74888.1, ECO:0000313|Proteomes:UP000017990};
RN   [1] {ECO:0000313|EMBL:CCZ74888.1, ECO:0000313|Proteomes:UP000017990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:21 {ECO:0000313|Proteomes:UP000017990};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ74888.1}.
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DR   EMBL; CBAN010000195; CCZ74888.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5U9N6; -.
DR   Proteomes; UP000017990; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:UniProt.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.10; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   InterPro; IPR029483; GH97_C.
DR   InterPro; IPR019563; GH97_catalytic.
DR   InterPro; IPR029486; GH97_N.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR35803; GLUCAN 1,4-ALPHA-GLUCOSIDASE SUSB-RELATED; 1.
DR   PANTHER; PTHR35803:SF2; RETAINING ALPHA-GALACTOSIDASE; 1.
DR   Pfam; PF14509; GH97_C; 1.
DR   Pfam; PF14508; GH97_N; 1.
DR   Pfam; PF10566; Glyco_hydro_97; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..653
FT                   /note="Alpha-glucosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004393718"
FT   DOMAIN          30..285
FT                   /note="Glycosyl-hydrolase 97 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14508"
FT   DOMAIN          289..552
FT                   /note="Glycosyl-hydrolase 97 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF10566"
FT   DOMAIN          554..650
FT                   /note="Glycosyl-hydrolase 97 C-terminal oligomerisation"
FT                   /evidence="ECO:0000259|Pfam:PF14509"
SQ   SEQUENCE   653 AA;  75111 MW;  AA34A4468C7EB748 CRC64;
     MRRKKIYLRT SALLVLIMLS TGTFAKDYIL HSPDHRVSVT IGISDSIGFN VIMDGKSIVK
     QAKIAFLTDM SADKRLKVRK VSRSSVNTVL HPVVSQKASM IADIYNQLRI DFSDRISLEW
     RAYDNGVSWR WLSNIKGEYK VTDEVAEFMF NKKDVVWYPG EKSFYSGNEP KFTKCTLENL
     GAKKLACLPV LFDINGVKVL ITEANLLDYA GMWLESSIGG KLRAIFPHYP KEKEIKGDRD
     EYVHSRENFI AWYSSPTEFP WRVIALARED KDLLNNTLVY QLATPAKDDF AWVKPGKALW
     DWWNNCNIYK VDFKAGMNTE TYKYLIDFAA SNGLEYVVLD EGWYDLSDIM KLSRDIDMDE
     LSAYGRSKNV GLVLWCTWVR LDEKLDEALK QFSKWGIKAI KVDFMSRDDQ EMVGFYTRVS
     REAAKYKLLV DFHGCYKPTG LYRTYPNVVT FEGVYGQEQC KGDRDKAINP DHNLILPFNR
     MVAGPMDYTP GAMENAHKQE WYPNWNEPMS IGTRCHQLAM YVVYESPLQM LSDSPTKYLA
     EPECMEFLRT VPTVWKQTIP LDCKVGEYVS IARQAFDGQW YIGCMTNSDS RELSIKLDFL
     PEGEYQIKIW KDGINATRNA KDFSIETIQV NKNTVLPVQM VSGGGYAAMI RKH
//